| Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells. | |
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MedLine Citation:
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PMID: 12490313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fungal metabolite apicidin (cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)) inhibited the growth of HL-60 cells in a concentration-dependent manner (100-1000 nM). At higher concentrations (>300 nM), cell death was induced. At 100 nM, it induced hyperacetylation of histone H4 time-dependently, while trichostatin A induced transient hyperacetylation. Apicidin (10-100 nM) increased the cells having nitroblue tetrazolium-reducing activity and expressing CD11b but not CD14 and CD15. The expression of CD11b by apicidin was long lasting, while that by trichostatin A was transient. In K562 cells, apicidin at 10-100 nM did not inhibit cell growth nor express CD11b, CD14 and CD15. Our findings indicate that apicidin inhibits proliferation and induces the early stage of differentiation of HL-60 cells. |
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Authors:
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JangJa Hong; Kenji Ishihara; Kouya Yamaki; Kenji Hiraizumi; Tadao Ohno; Jong Woong Ahn; OkPyo Zee; Kazuo Ohuchi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 189 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-19 Completed Date: 2003-02-28 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 197-206 Citation Subset: IM |
Affiliation:
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Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation
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drug effects Antigens, CD11b / analysis Antigens, CD14 / analysis Antigens, CD15 / analysis Apoptosis / drug effects Cell Differentiation / drug effects Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology* HL-60 Cells / cytology, drug effects* Histone Deacetylase Inhibitors* Histones / metabolism Humans K562 Cells / drug effects Neoplasm Proteins / antagonists & inhibitors*, metabolism Peptides, Cyclic / pharmacology* Protein Processing, Post-Translational / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD11b; 0/Antigens, CD14; 0/Antigens, CD15; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Histones; 0/Neoplasm Proteins; 0/Peptides, Cyclic; 0/apicidin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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