Document Detail

Apical sparing in tako-tsubo cardiomyopathy.
MedLine Citation:
PMID:  16780446     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tako-tsubo cardiomyopathy (TTC) is an acute reversible cause of segmental myocardial dysfunction that is poorly understood. We have noted a variant of this condition where a tiny segment at the apex retains some contractile function. This paper delineates the frequency of this variant relative to the classical form and the clinical differences between patients suffering from the two forms. METHODS: All cases of TTC (n = 35) were identified from our infarct angiography database and separated on the basis of apical sparing (n = 14) or no apical sparing (n = 21). RESULTS: Compared with the classical form, those with apical sparing were significantly younger (63 +/- 12 vs 72 +/- 13 years) and were more likely premenopausal (5/14 vs 0/21) and had higher ejection fractions (35 +/- 6% vs 32 +/- 4%). There was a trend towards higher recurrence (4/21 vs 0/14). There were no differences in time or season of presentation, precipitant stressor, premorbid drug therapy, haemodynamics at catheterization or acute outcomes. CONCLUSION: The apical sparing variant of TTC is common, accounting for 40% of cases. While the patients are younger and more likely premenopausal, there are no other distinguishing features between the classical and the variant form.
I Abdulla; S Kay; C Mussap; G I C Nelson; H H Rasmussen; P S Hansen; M R Ward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Internal medicine journal     Volume:  36     ISSN:  1445-5994     ISO Abbreviation:  Intern Med J     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101092952     Medline TA:  Intern Med J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  414-8     Citation Subset:  IM    
Department of Medicine, University of Sydney, Sydney, NSW, Australia.
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MeSH Terms
Age Factors
Aged, 80 and over
Cardiomyopathies / classification*,  diagnosis*,  physiopathology
Heart / physiopathology*
Middle Aged
Stroke Volume
Ventricular Dysfunction, Left / diagnosis*,  physiopathology

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