Document Detail


Apical hypertrophic cardiomyopathy: clinical and metabolic studies.
MedLine Citation:
PMID:  6686528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Among the hypertrophic non-obstructive cardiomyopathies, a particular group of patients with concentric apical hypertrophy can be described. We studied seven patients (five men and two women) who underwent heart catheterization because they had giant negative T waves in the precordial leads. M-mode and two-dimensional echocardiograms revealed no obstruction within the outflow tract of the ventricle. Coronary angiography was normal in all cases. None of these patients demonstrated any significant peak systolic pressure gradient in the outflow tract. A characteristic spade-like configuration (concentric apical hypertrophy) was observed in the right anterior oblique ventriculogram at end diastole. The apical thickness reached 17.2 +/- 0.85 mm and was significantly greater than mid-anterior wall thickness (9.8 +/- 2.14 mm). In five cases, atrial pacing with coronary arterial and venous lactate sampling revealed abnormalities in myocardial metabolism. With a mean follow up of 43 months, three patients remain asymptomatic and one had heart failure. ECG abnormalities were unchanged and echocardiograms showed an increase of the septal and posterior wall thickness, suggesting a transformation in concentric diffuse hypertrophic cardiomyopathy.
Authors:
M E Bertrand; P Y Tilmant; J M Lablanche; F A Thieuleux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  4 Suppl F     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-03-22     Completed Date:  1984-03-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiac Pacing, Artificial
Cardiomyopathy, Hypertrophic / diagnosis*,  metabolism
Cineangiography
Coronary Angiography
Echocardiography
Electrocardiography
Female
Heart Catheterization
Humans
Lactates / metabolism*
Lactic Acid
Male
Middle Aged
Myocardial Contraction
Myocardium / metabolism*
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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