| Apheresis induces oxidative stress in blood cells. | |
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MedLine Citation:
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PMID: 20438538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress mediates damage to various cells and is thought to be involved in various pathologies, including hereditary and acquired hemolytic anemias. It is induced by a multitude of physiological and environmental factors, including extracorporeal manipulation of blood. As a result, hemodialysis induces oxidative damage to red blood cells, thereby increasing their susceptibility to hemolysis and shortening their life span. We studied the effect of apheresis on the oxidative status of blood components. Using flow cytometric measurements, we showed that red blood cells, lymphocytes, monocytes, and polymorphonuclear cells undergo oxidative stress induced by the procedure. Their reactive oxygen species and externalization of phosphatidylserine increased, while their levels of reduced glutathione decreased. This oxidative stress, which may be caused by a direct interaction with the membranous system, may lead to cellular abnormalities with clinical consequences such as hemolysis and platelet hyperactivation. |
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Authors:
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Johnny Amer; Shoshana Frankenburg; Eitan Fibach |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 14 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-04 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 166-71 Citation Subset: IM |
Affiliation:
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Department of Health Professions, Al-Quds University, Abu Dies, Jerusalem, Israel. johnnyamer@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Cells* Blood Component Removal / adverse effects*, methods Flow Cytometry Glutathione / metabolism Humans Oxidative Stress* Phosphatidylserines / metabolism Reactive Oxygen Species / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Phosphatidylserines; 0/Reactive Oxygen Species; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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