| Aphasia induced by gliomas growing in the ventrolateral frontal region: Assessment with diffusion MR tractography, functional MR imaging and neuropsychology. | |
| | |
MedLine Citation:
|
PMID: 22236887 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
INTRODUCTION: Lesions in the ventrolateral region of the dominant frontal lobe have been historically associated with aphasia. Recent imaging results suggest that frontal language regions extend beyond classically defined Broca's area to include the ventral precentral gyrus (VPCG) and the arcuate fasciculus (AF). Frontal gliomas offer a unique opportunity to identify structures that are essential for speech production. The aim of this prospective study was to investigate the correlation between language deficits and lesion location in patients with gliomas. METHODS: Nineteen patients with glioma and 10 healthy subjects were evaluated with diffusion tensor imaging magnetic resonance (MR) tractography, functional MR (verb generation task) and the Aachener Aphasie Test. Patients were divided into two groups according to lesion location with respect to the ventral precentral sulcus: (i) anterior (n=8) with glioma growing in the inferior frontal gyrus (IFG) and underlying white matter; (ii) posterior (n=11) with glioma growing in the VPCG and underlying white matter. Virtual dissection of the AF, frontal intralobar tract, uncinate fasciculus (UF) and inferior frontal occipital fasciculus (IFOF) was performed with a deterministic approach. RESULTS: Seven posterior patients showed aphasia classified as conduction (4), Broca (1), transcortical motor (1) and an isolated deficit of semantic fluency; one anterior patient had transcortical mixed aphasia. All posterior patients had invasion of the VPCG, however only patients with aphasia had also lesion extension to the AF as demonstrated by tractography dissections. All patients with language deficits had high grade glioma. Groups did not differ regarding tumour volume. A functional pars opercularis was identified with functional MR imaging (fMRI) in 17 patients. CONCLUSIONS: Gliomas growing in the left VPCG are much more likely to cause speech deficits than gliomas infiltrating the IFG, including Broca's area. Lesion extension to the AF connecting frontal to parietal and temporal regions is an important mechanism for the appearance of aphasia. |
| | |
Authors:
|
Alberto Bizzi; Simone Nava; Francesca Ferrè; Gianmarco Castelli; Domenico Aquino; Francesca Ciaraffa; Giovanni Broggi; Francesco Dimeco; Sylvie Piacentini |
Related Documents
:
|
22228127 - Ct diagnosis of the nature of bowel obstruction: morphological evaluation of the transi... 3310877 - Computerized tomography-guided stereotactic dentatotomy. 21404957 - Chronic familial mediterranean fever with development of secondary amyloidosis. 21593437 - Identification of pure subcortical vascular dementia using 11c-pittsburgh compound b. 2594187 - Traumatic lumbosacral nerve root meningoceles. the value of myelography, ct and mri in ... 3383917 - Blink reflex in stroke: follow-up and correlation with function and ct parameters. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
|
Title: Cortex; a journal devoted to the study of the nervous system and behavior Volume: - ISSN: 1973-8102 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0100725 Medline TA: Cortex Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Srl. All rights reserved. |
Affiliation:
|
Neuroradiology, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Systemic therapy for advanced endometrial cancer.
Next Document: Postural control in multiple sclerosis: Effects of disability status and dual task.