| Apelin: a novel marker for the patients with first ST-elevation myocardial infarction. | |
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MedLine Citation:
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PMID: 20676956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To date, only animal studies have been concerned with apelin involvement in acute myocardial ischemia. The aim of this study was to investigate apelin measurements in low-risk patients with first ST-elevation myocardial infarction (STEMI) and to assess if apelin may feature as a marker of left ventricular (LV) injury and prognosis. In 78 consecutive patients (mean age 67 +/- 11.5 years, 24 women) with first STEMI treated with primary percutaneous coronary intervention, plasma apelin-36 concentrations were measured twice: on admission and on the 5th day of hospitalization. Left ventricle ejection fraction (LVEF) was applied as marker of LV injury. Composite endpoint (CEP), which included death, stroke, and recurrent ischemic event, was assessed after 1 year follow-up. On the first day, median apelin-36 concentration was 2138.5 pg/ml and on the 5th day was significantly lower, 2008.3 pg/ml (P = 0.002). There were no significant differences found in apelin-36 concentrations between patients with normal and low LVEF. In both groups significant reductions were found in apelin-36 concentrations measured in 5-day intervals (P = 0.04 and P = 0.008, respectively). After a 1-year follow-up, only one patient died and 19 patients (24.3%) had reached CEP. No difference in baseline apelin-36 concentrations were found in the group of patients who reached CEP compared with those without CEP. However, in both groups concentrations significantly decreased after 5 days (P = 0.04 and P = 0.013, respectively). Apelin-36 concentrations are reduced in low risk first STEMI patients during the first days regardless of the degree of LV dysfunction and prognosis. |
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Authors:
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Agnieszka M Kuklinska; Bozena Sobkowicz; Robert Sawicki; Wlodzimierz J Musial; Ewa Waszkiewicz; Swietlana Bolinska; Jolanta Małyszko |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-31 |
Journal Detail:
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Title: Heart and vessels Volume: 25 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 363-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medical University, Bialystok, Poland. agnieszka.kuklinska@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon, Coronary* / adverse effects, mortality Biological Markers / blood Chi-Square Distribution Down-Regulation Female Humans Intercellular Signaling Peptides and Proteins / blood* Male Middle Aged Myocardial Infarction / blood*, mortality, physiopathology, therapy* Pilot Projects Poland Prospective Studies Recurrence Risk Assessment Risk Factors Stroke / etiology Stroke Volume Time Factors Treatment Outcome Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/APLN protein, human; 0/Biological Markers; 0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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