Document Detail


Apelin: a novel marker for the patients with first ST-elevation myocardial infarction.
MedLine Citation:
PMID:  20676956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To date, only animal studies have been concerned with apelin involvement in acute myocardial ischemia. The aim of this study was to investigate apelin measurements in low-risk patients with first ST-elevation myocardial infarction (STEMI) and to assess if apelin may feature as a marker of left ventricular (LV) injury and prognosis. In 78 consecutive patients (mean age 67 +/- 11.5 years, 24 women) with first STEMI treated with primary percutaneous coronary intervention, plasma apelin-36 concentrations were measured twice: on admission and on the 5th day of hospitalization. Left ventricle ejection fraction (LVEF) was applied as marker of LV injury. Composite endpoint (CEP), which included death, stroke, and recurrent ischemic event, was assessed after 1 year follow-up. On the first day, median apelin-36 concentration was 2138.5 pg/ml and on the 5th day was significantly lower, 2008.3 pg/ml (P = 0.002). There were no significant differences found in apelin-36 concentrations between patients with normal and low LVEF. In both groups significant reductions were found in apelin-36 concentrations measured in 5-day intervals (P = 0.04 and P = 0.008, respectively). After a 1-year follow-up, only one patient died and 19 patients (24.3%) had reached CEP. No difference in baseline apelin-36 concentrations were found in the group of patients who reached CEP compared with those without CEP. However, in both groups concentrations significantly decreased after 5 days (P = 0.04 and P = 0.013, respectively). Apelin-36 concentrations are reduced in low risk first STEMI patients during the first days regardless of the degree of LV dysfunction and prognosis.
Authors:
Agnieszka M Kuklinska; Bozena Sobkowicz; Robert Sawicki; Wlodzimierz J Musial; Ewa Waszkiewicz; Swietlana Bolinska; Jolanta Małyszko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-31
Journal Detail:
Title:  Heart and vessels     Volume:  25     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  363-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Medical University, Bialystok, Poland. agnieszka.kuklinska@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Balloon, Coronary* / adverse effects,  mortality
Biological Markers / blood
Chi-Square Distribution
Down-Regulation
Female
Humans
Intercellular Signaling Peptides and Proteins / blood*
Male
Middle Aged
Myocardial Infarction / blood*,  mortality,  physiopathology,  therapy*
Pilot Projects
Poland
Prospective Studies
Recurrence
Risk Assessment
Risk Factors
Stroke / etiology
Stroke Volume
Time Factors
Treatment Outcome
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/APLN protein, human; 0/Biological Markers; 0/Intercellular Signaling Peptides and Proteins

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