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Apelin levels in normal pregnancy.
MedLine Citation:
PMID:  21521329     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:  Apelin is an adipokine secreted from adipose and other tissues with increased expression in obesity, role in glucose metabolism and atherosclerosis, as well as in oxidative stress. Pregnancy is considered a state of hyperlipidemia, oxidative stress and decreased insulin sensitivity. The aim of the present study is to investigate levels of apelin in human pregnancy and its relation to insulin sensitivity. Patients and measurements:  One hundred and six pregnant women (24(th) - 28(th) week of gestation), aged 27.9 ± 0.4 years, were compared to 106 age-matched healthy, non-pregnant women (controls). Measured parameters included serum levels of glucose, insulin, apelin, adiponectin, total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL), triglycerides (TG) and oxidized LDL (ox-LDL). The Body Mass Index (BMI) and the QUantitative Insulin sensitivity ChecK Index (QUICKI) were calculated as well. Results:  BMI, serum lipids and insulin levels were significantly higher, whereas serum apelin and glucose levels were lower in the pregnancy group compared to the control group. There was a significant negative correlation between apelin and adiponectin, in both groups. Additionally, apelin was negatively correlated to ox-LDL and HDL-cholesterol in the pregnancy group. Conclusions:  Although strongly correlated with adiponectin, apelin cannot be used as a marker of insulin sensitivity, but it could serve as a marker of oxidative stress in pregnancy.
Authors:
Anargyros Kourtis; Athina Giomisi; Maria Mouzaki; Kali Makedou; Athanasios Anastasilakis; Konstantinos Toulis; Spyridon Gerou; Elpida Gavana; Theodoros Agorastos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-5
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Affiliation:
4th Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece Clinic of Obstetrics and Gynaecology, 424 Military Hospital, Thessaloniki, Greece Department of Endocrinology, 424 Military Hospital, Thessaloniki, Greece Laboratories "Analysis", Thessaloniki, Greece.
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