| Apathy and verbal fluency in STN-stimulated PD patients. An observational follow-up study. | |
| | |
MedLine Citation:
|
PMID: 17426909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate apathy and its relation to verbal fluency tasks in a consecutive series of 19 patients with Parkinson's disease (PD) submitted to deep brain stimulation of the subthalamic nucleus (DBS of STN). METHODS: 19 consecutive PD patients submitted to bilateral DBS of STN were studied for apathy pre-operatively and 17 months after surgery. The PD patients underwent a battery of cognitive tests assessing reasoning, memory and frontal executive functions, including phonemic and categorial fluency tasks. The Beck Depression Inventory (BDI) was used for depression. Apathy was assessed by means of the Apathy Scale (AS). In order to quantify changes among individual patients, the clinical criterion of more or less than 1 SD (standard z-score) was used to register a patient as improved or worsened, respectively. RESULTS: After surgery, apathy scores did not change and mood improved (p < 0.02), while a significant worsening was found in the phonemic fluency (p < 0.001). The percentage of patients with an apathy score above the recommended cut-off value (14) was 42% both before and after DBS of STN. Individual outcomes on the apathy scale (1 SD criterion) evidenced that 53% of the patients remained stable, 16% improved, while 31% worsened. This last percentage reduced to 21% (4/19) when considering only the PD patients with an apathy score > or =14 after surgery. No significant correlation was found between the apathy scores variation and any of the neurological variables considered, and, in particular, no correlation was found between apathy and verbal fluency. CONCLUSIONS: The results of the present study suggest that DBS of STN does not necessarily induce apathy even if individual patients show a moderate post-operative worsening of apathetic symptoms. |
| | |
Authors:
|
L Castelli; M Lanotte; M Zibetti; M Caglio; L Rizzi; A Ducati; B Bergamasco; L Lopiano |
Related Documents
:
|
22104009 - Parkinsonian signs and symptoms in adults with a history of sydenham's chorea. 22448309 - Should we look for celiac disease among all patients with liver function test abnormali... 21034369 - Pupil light reflex in parkinson's disease: evaluation with pupillometry. 3190499 - Slowing of cognitive processing in progressive supranuclear palsy. a comparison with pa... 19884649 - Air temperature and inflammatory and coagulation responses in men with coronary or pulm... 22398059 - Induction of psoriasis with anti-tnf agents in patients with inflammatory bowel disease... 23146419 - Complex visual hallucinations in a parkinson patient: don't blame james if it's charles... 17226899 - Differential diagnosis between functional and organic intestinal disorders: is there a ... 22975639 - Alu-based cell-free dna: a potential complementary biomarker for diagnosis of colorecta... |
Publication Detail:
|
Type: Journal Article Date: 2007-04-11 |
Journal Detail:
|
Title: Journal of neurology Volume: 254 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-11-16 Completed Date: 2008-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1238-43 Citation Subset: IM |
Affiliation:
|
Dept. of Neuroscience, University of Turin, via Cherasco 15, 10126 Turin, Italy. castelli_lorys@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antidepressive Agents
/
therapeutic use Antipsychotic Agents / therapeutic use Behavioral Symptoms / diagnosis*, etiology Deep Brain Stimulation* / adverse effects Female Follow-Up Studies Humans Male Middle Aged Mood Disorders / diagnosis, etiology Neuropsychological Tests Parkinson Disease / complications, physiopathology*, therapy* Speech Disorders / diagnosis*, etiology Subthalamic Nucleus / physiopathology*, surgery Time Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antidepressive Agents; 0/Antipsychotic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination of pain and response to methylprednisolone in Guillain-Barré syndrome.
Next Document: Lumbar spinal stenosis: assessment of cauda equina involvement by electrophysiological recordings.