| Aortomyoplasty: hemodynamics and comparison to the intraaortic balloon pump. | |
| | |
MedLine Citation:
|
PMID: 12788660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Aortomyoplasty (AMP), a procedure in which the latissimus dorsi muscle (LDM) is wrapped around the aorta and stimulated during diastole, is a potential method of chronic counterpulsation. Counterpulsation by the intraaortic balloon pump (IABP) is a proven treatment for ischemic coronary syndrome and heart failure but cannot be used chronically. This study examined the long-term potential of a unique AMP configuration and compared its performance to the IABP. MATERIALS AND METHODS: AMP was done using a wringer configuration (AMP-W) in nine dogs. Six and 12 months later, acute hemodynamic augmentation was evaluated by measuring differences in mean diastolic aortic pressure (mDAP), peak left ventricular pressure (pLVP), and the endocardial viability ratio (EVR) between stimulated and unstimulated beats. RESULTS: The diastolic augmentation obtained by AMP-W at 6 months and by AMP-W and IABP at 12 months was statistically significant. Additionally, the enhancements in EVR (16.1 +/- 4.3%), mDAP (8.6 +/- 2.5%), and pLVP (-1.8 +/- 1.0%) at 6 months were similar to those in EVR (19.1 +/- 5.2%), mDAP (13.1 +/- 3.6%), and pLVP (-0.8 +/- 1.3%) at 12 months. Most importantly, the augmentation obtained by AMP-W at 12 months was similar to that of the IABP: EVR (17.1 +/- 5.9%), mDAP (13.4 +/- 6.7%), and pLVP (-1.5 +/- 0.8%). CONCLUSIONS: AMP-W is a safe, robust procedure, capable of providing counterpulsation equivalent to the IABP, 12 months following surgery. The potential for AMP-W to offer chronic counterpulsation and to benefit the ischemic heart should be investigated further. |
| | |
Authors:
|
John T Sherwood; Steve J Schomisch; Dirk R Thompson; David T George; Brian L Cmolik |
Publication Detail:
|
Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The Journal of surgical research Volume: 110 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 2003 Apr |
Date Detail:
|
Created Date: 2003-06-05 Completed Date: 2003-07-08 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
|
Languages: eng Pagination: 315-21 Citation Subset: IM |
Affiliation:
|
Cardiothoracic Surgery, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106-5011, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / surgery* Dogs Electric Stimulation / methods* Hemodynamics / physiology Intra-Aortic Balloon Pumping Male Muscle, Skeletal / transplantation* Myocardial Ischemia / surgery* Time Factors Treatment Outcome Vascular Surgical Procedures / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymi...
Next Document: Myoglobin gene expression attenuates hepatic ischemia reperfusion injury.