| Aortic wall remodeling in rats with nitric oxide deficiency treated by enalapril or verapamil. | |
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MedLine Citation:
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PMID: 15200273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty mature male Wistar rats were maintained alive for 40 days, separated in four groups of five rats each: control, L-NAME (LN), L-NAME + Enalapril (LN + E), L-NAME + Verapamil (LN + V). Blood pressure (BP), left ventricular (LV) mass index, and aortic wall parameters were analyzed: aortic wall thickness, tunica media sectional area, surface density of lamellae (Sv[lamellae]), and smooth muscle cell nuclear profiles per section (SMC). At the end of the experiment, the LN group showed high BP and a high LV mass index (cardiac hypertrophy). The control group and the other groups showed significant differences in aortic wall thickness, tunica media sectional area, Sv[lamellae], and SMC. When comparing the LN group with both the LN + E group and the LN + V group, aortic thickness was not different. Tunica media sectional area and SMC differed between the LN group and the LN + E group. There were also differences between the LN group and the LN + V group in SMC. The Sv[lamellae] decreased in the following sequence: control group > LN group = LN + E group > LN + V group. In conclusion, treatment with enalapril and verapamil shows partial efficiency in preventing or treating aortic wall tunica media hypertrophy, suggesting that these alterations are due to a mechanism other than blood pressure control, where nitric oxide synthesis inhibition could be involved. |
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Authors:
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Leila M M Pereira; Daniele G Bezerra; Carlos A Mandarim-de-Lacerda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pathology, research and practice Volume: 200 ISSN: 0344-0338 ISO Abbreviation: Pathol. Res. Pract. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-06-17 Completed Date: 2004-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806109 Medline TA: Pathol Res Pract Country: Germany |
Other Details:
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Languages: eng Pagination: 211-7 Citation Subset: IM |
Affiliation:
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Laboratório de Morfometria & Morfologia Cardiovascular, Universidade do Estado do Rio de Janeiro, Centro Biomédico, Av 28 de Setembro, 87 fds. CEP:20551-030, Rio de Janeiro, RJ, Brazil. mandarim@uerj.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology* Animals Aorta, Thoracic / drug effects, pathology* Blood Pressure / drug effects Calcium Channel Blockers / pharmacology* Disease Models, Animal Drug Therapy, Combination Enalapril / pharmacology* Heart Ventricles / drug effects, pathology Male Muscle, Smooth, Vascular / drug effects, metabolism, pathology NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / deficiency* Rats Rats, Wistar Verapamil / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 52-53-9/Verapamil; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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