Document Detail

Aortic valve sclerosis as a marker of active atherosclerosis.
MedLine Citation:
PMID:  11827633     Owner:  NLM     Status:  MEDLINE    
Aortic sclerosis is a calcific disease of the aortic valvular leaflets defined as focal leaflet thickening without significant obstruction to left ventricular outflow. Several clinical factors are associated with calcific aortic valve disease, including male sex, smoking, hypertension, age, hypercholesterolemia, and diabetes. Histologic and biochemical studies suggest similarities between the mechanisms involved in the development of aortic sclerosis and atherosclerosis, suggesting these two diseases may share common pathophysiologic mechanisms. In a recent prospective trial, the presence of aortic sclerosis was associated with an approximately 50% increase in cardiovascular mortality and myocardial infarction, even after correction for age, gender, known coronary artery disease, and clinical factors associated with a aortic sclerosis.
Kelley R Branch; Kevin D O'Brien; Catherine M Otto
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current cardiology reports     Volume:  4     ISSN:  1523-3782     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-06     Completed Date:  2002-04-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Division of Cardiology, University of Washington Medical Center, 1959 NE Pacific Street, Box 356422, Seattle, WA 98195-6422, USA.
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MeSH Terms
Aortic Valve / pathology*
Aortic Valve Stenosis / complications,  drug therapy,  pathology
Arteriosclerosis / complications,  drug therapy,  pathology*
Calcinosis / complications,  drug therapy,  pathology*
Risk Factors
Sclerosis / complications,  drug therapy,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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