Document Detail

Aortic valve replacement. Aortic root versus coronary sinus perfusion with blood cardioplegic solution.
MedLine Citation:
PMID:  1614198     Owner:  NLM     Status:  MEDLINE    
The role of retrograde coronary sinus cardioplegia in patients undergoing aortic valve replacement for aortic stenosis alone or in combination with myocardial revascularization has not been fully defined. Sixty-three patients undergoing elective aortic valve replacement received cold potassium blood cardioplegic solution via either the aortic root (36 patients) or the coronary sinus (27 patients). The patients were similar with respect to age, degree of aortic stenosis, ventricular function, severity of coronary artery disease, crossclamp time, completeness of revascularization, and mean volume and temperature of the infusion solution. The mean septal temperature and the release of myocardium-specific isoenzyme in the first 2 hours after crossclamp removal was higher in the retrograde group (p less than 0.008). Right and left ventricular function was preserved equally in the two groups, and volume-loading studies suggested improved diastolic performance in patients having retrograde cardioplegia. There were no differences between the two groups with respect to clinical outcome. We conclude that coronary sinus cardioplegia is as safe as aortic root perfusion for myocardial preservation in patients undergoing elective aortic valve replacement.
A C Fiore; K S Naunheim; L R McBride; D G Pennington; G C Kaiser; J Castanis; C J Daake; V L Willman; H B Barner
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  104     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-7; discussion 137-8     Citation Subset:  AIM; IM    
Department of Surgery, St. Louis University Medical Center, Mo.
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MeSH Terms
Aortic Valve
Aortic Valve Stenosis / surgery*
Cardioplegic Solutions / administration & dosage*
Coronary Vessels
Heart Arrest, Induced / methods*
Heart Valve Prosthesis*
Middle Aged
Myocardial Reperfusion Injury / prevention & control*
Myocardial Revascularization
Reg. No./Substance:
0/Cardioplegic Solutions
Comment In:
J Thorac Cardiovasc Surg. 1993 Aug;106(2):370   [PMID:  8341079 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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