Document Detail

Aortic valve replacement in a patient with alpha-thalassemia.
MedLine Citation:
PMID:  21030927     Owner:  NLM     Status:  MEDLINE    
Cardiac valve disease resulting from elastic tissue defects has been demonstrated in patients with beta-thalassemia; however, valve disorders of patients with alpha-thalassemia have been rarely discussed. We present the case of a patient with alpha-thalassemia and severe aortic regurgitation with left ventricular dysfunction. The patient underwent successful aortic valve replacement with mechanical prosthesis. Histopathology of the excised valve showed elastic tissue disruption and chronic thrombus on the ventricular side. Hypercoagulative states have been observed in patients with alpha-thalassemia as beta-thalassemia; therefore special attention should be taken in perioperative anticoagulation therapy.
Tadashi Omoto; Takeo Tedoriya; Yasuyuki Kondo; Hirofumi Izuka; Masaya Oi; Naoko Nagano; Tadamasa Miyauchi; Noboru Ishikawa; Hitoshi Kasegawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  16     ISSN:  2186-1005     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-04-21     Revised Date:  2012-06-18    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  365-6     Citation Subset:  IM    
Department of Surgery, Division of Thoracic and Cardiovascular Surgery Showa University, Tokyo, Japan.
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MeSH Terms
Aortic Valve
Aortic Valve Insufficiency / etiology,  surgery*
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation
Ventricular Dysfunction, Left / etiology
alpha-Thalassemia / complications*

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