Document Detail

Aortic valve replacement improves survival in severe aortic stenosis associated with severe pulmonary hypertension.
MedLine Citation:
PMID:  17588389     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Severe pulmonary arterial hypertension in patients with severe aortic stenosis (AS) carries a poor prognosis. There are limited data on the effect of aortic valve replacement (AVR) in these patients. METHODS: Our echocardiographic database between 1993 and 2003 was searched for patients with severe AS defined as a Doppler estimated aortic valve area of 0.8 cm2 or less and severe pulmonary hypertension defined as a pulmonary arterial systolic pressure 60 mm Hg or greater. Of the 740 patients with severe AS, 119 (16%) had severe pulmonary hypertension forming the study cohort. The AVR was performed in 36 (30%) of these patients. Survival of patients with and without AVR were compared and adjusted for comorbidities and group differences using the Cox regression model. RESULTS: Characteristics of patients with severe pulmonary hypertension; age 75 +/- 13 years, 39% women, left ventricular ejection fraction 41 +/- 20%. Patients who underwent AVR had a significantly higher five-year survival of 65% compared with 20% for those treated medically (p < 0.0001). The relative mortality risk associated with AVR was 0.28 (95% confidence interval 0.22 to 0.36) and was independent of age, gender, ejection fraction, diabetes, coronary disease, serum creatinine level, and concomitant medical therapy such as beta blockers, angiotensin converting inhibitors, and statins. The benefit of AVR was further supported by sensitivity and propensity score analyses. Patients on conservative therapy had a 30-day mortality of 30% and a one-year mortality of 70%. CONCLUSIONS: Aortic valve replacement in patients with severe pulmonary hypertension secondary to severe AS is associated with a huge survival benefit. Medical therapy alone carries a dismal prognosis and AVR should be considered urgently in severe AS patients with severe pulmonary hypertension.
Ramdas G Pai; Padmini Varadarajan; Nikhil Kapoor; Ramesh C Bansal
Related Documents :
24348749 - A voxel-map quantitative analysis approach for atherosclerotic noncalcified plaques of ...
16292989 - Sitaxsentan: a novel endothelin-a receptor antagonist for pulmonary arterial hypertension.
12107399 - Developments in therapeutics for pulmonary arterial hypertension.
564519 - Acute experimental emotional stress and natural history of arterial hypertension.
3033179 - Effect of converting enzyme inhibitors on hypertensive large arteries in humans.
10980899 - Current management of patients with pulmonary hypertension and right ventricular insuff...
6396309 - Percutaneous treatment of small bowel obstruction due to a gastrostomy tube.
18442549 - Arterial access through the right subclavian artery in surgery of the aortic arch impro...
9052539 - The effects of femoral intramedullary reaming on pulmonary function in a sheep lung model.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  84     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  AIM; IM    
Loma Linda University Medical Center, Loma Linda, California, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aortic Valve / surgery*
Aortic Valve Stenosis / mortality,  physiopathology,  surgery*
Hypertension, Pulmonary / mortality,  physiopathology,  surgery*
Middle Aged
Regression Analysis
Retrospective Studies
Ventricular Function, Left
Comment In:
Ann Thorac Surg. 2007 Jul;84(1):85-6   [PMID:  17588390 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Meta-analysis of valve hemodynamics and left ventricular mass regression for stentless versus stente...
Next Document:  Early switch from vancomycin to oral linezolid for treatment of gram-positive heart valve endocardit...