Document Detail

Aortic valve grafts in the rat: evidence for rejection.
MedLine Citation:
PMID:  9434683     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The histopathologic changes of fresh rat aortic valve allografts over time and the effect of cryopreservation were examined. METHODS: Fifty-six syngeneic and allogeneic rat aortic valves were transplanted, either fresh or after cryopreservation, and then at different time points they were explanted and histologically examined in a blinded fashion. RESULTS: Histopathologic changes in the first week are similar in syngeneic and allogeneic grafts. Fresh syngeneic grafts and leaflets retained normal structure up to 56 days. Allogeneic grafts showed retrovalvular thrombus formation with leaflet ghosts and neointimal proliferation. Cryopreservation did not alter this process. CONCLUSIONS: Cardiac allograft valves in the rat model undergo changes that are characteristic of cell-mediated rejection and lead to valve failure.
A Moustapha; D B Ross; B Bittira; D Van-Velzen; V C McAlister; C L Lannon; T D Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  114     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-12     Completed Date:  1998-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  891-902     Citation Subset:  AIM; IM    
Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
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MeSH Terms
Aortic Valve / immunology,  pathology,  transplantation*
Graft Rejection / pathology*
Rats, Inbred BN
Rats, Inbred Lew
Thrombosis / immunology,  pathology
Time Factors
Transplantation, Homologous
Transplantation, Isogeneic

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