| Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients. | |
| | |
MedLine Citation:
|
PMID: 21519280 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Arterial stiffness is an independent predictor of cardiovascular events and mortality in hypertensive patients. The influence of different antihypertensive drug classes on improving arterial stiffness beyond blood pressure reduction is not widely available. We aimed to determine whether the artery stiffness can be improved because of antihypertensive treatments independently of blood pressure lowering. METHODS: We conducted a meta-analysis of individual data from 15 randomized, controlled, double-blind, parallel group trials performed in our laboratory between 1987 and 1994. The primary endpoint was the changes of carotid-femoral pulse wave velocity (PWV) after treatment in 294 patients with mild-to-moderate essential hypertension untreated. Treatments tested were placebo (n = 88), angiotensin-converting enzyme inhibitors (ACEIs) (n = 75), calcium antagonists (n = 75), beta-blocker (n = 30), and diuretic (n = 26). RESULTS: In the short-term and long-term trials, PWV decreased significantly by -0.75 and -1.3 m/s in the active treatment group compared with by +0.17 and -0.44 m/s in the placebo group, respectively. Active treatment was independently related to the changes in PWV and explained 5 and 4% of the variance in the short-term and long-term trials, respectively. In the short-term trials, ACEIs were more effective than calcium antagonists and placebo on improving arterial stiffness. In the long-term trials, ACEI, calcium antagonists, beta-blocker, and diuretic reduced significantly PWV compared to placebo. CONCLUSION: Our study shows that antihypertensive treatments improve the arterial stiffness beyond their effect on blood pressure. |
| | |
Authors:
|
Kim-Thanh Ong; Samuel Delerme; Bruno Pannier; Michel E Safar; Athanase Benetos; Stéphane Laurent; Pierre Boutouyrie; |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-23 |
Journal Detail:
|
Title: Journal of hypertension Volume: - ISSN: 1473-5598 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
aAssistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, France bINSERM U970, France cUniversité Paris - Descartes, France dAssistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France eCentre Hospitalier M.H. Manhes, Fleury Mérogis, France fAssistance Publique - Hôpitaux de Paris, Hôtel-Dieu, Centre de Diagnostic et de Thérapeutique, Paris, France gCentre Hospitalier Universitaire de Nancy, INSERM U691, Université de Nancy, Nancy, France * A complete list of authors is included in Acknowledgement section. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between ADRA1A gene and the metabolic syndrome: candidate genes and functional counterpa...
Next Document: Esophageal pH Monitoring with the BRAVO™ Capsule: Experience in a Large Number of Patients at a Si...