Document Detail

Aortic stiffness and pulse wave reflection in young subjects with migraine: A case-control study.
MedLine Citation:
PMID:  20837963     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Migraine has been associated with an increased risk for ischemic stroke and other cardiovascular (CV) events, including angina, myocardial infarction, and CV death, but the mechanisms that link migraine to CV disease remain uncertain. We hypothesized that aortic pulse wave velocity (PWV), a direct measure of aortic stiffness and an independent predictor of stroke and CV disease, may be increased in young migraineurs with no overt CV disease or major CV risk factors.
METHODS: We studied 60 subjects with migraine (age 33 ± 8 years, 85% women, blood pressure 119/74 ± 11/9 mm Hg) and 60 age-, sex-, and blood pressure-matched healthy control subjects. In all participants, carotid-femoral PWV and aortic augmentation index were determined by applanation tonometry. Cases and controls were free from overt CV disease, diabetes, and major CV risk factors.
RESULTS: Subjects with migraine had a higher aortic PWV (7.6 ± 1.2 vs 6.4 ± 1.1 m × s(-1), p < 0.001) and aortic augmentation (heart rate-adjusted augmentation index, 0.17 ± 0.13 vs 0.08 ± 0.15, p < 0.001) than matched control subjects. Migraine patients with aura (n = 17) had higher aortic PWV than those without aura (n = 43; 8.2 ± 1.2 vs 7.4 ± 1.1 m × s(-1), p = 0.027). Age, mean arterial pressure as a measure of distending pressure, and migraine (all p < 0.05) independently predicted aortic PWV when a consistent number of CV risk factors was simultaneously controlled for.
CONCLUSIONS: Migraine is independently associated with increased aortic stiffness and enhanced pressure wave reflection. This finding, obtained in young subjects without major CV risk factors, may represent one possible mechanism underlying the increased CV risk in migraine patients.
G Schillaci; P Sarchielli; I Corbelli; G Pucci; L Settimi; M R Mannarino; P Calabresi; E Mannarino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  75     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2010-10-08     Revised Date:  2010-11-24    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  960-6     Citation Subset:  AIM; IM    
Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Perugia.
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MeSH Terms
Aorta / physiopathology*
Blood Flow Velocity / physiology*
Blood Pressure / physiology
Brachial Plexus / physiology
Cardiovascular Diseases / physiopathology
Carotid Arteries / physiopathology
Case-Control Studies
Femoral Artery / physiopathology
Middle Aged
Migraine Disorders / physiopathology*
Pulsatile Flow
Regression Analysis
Young Adult
Comment In:
Neurology. 2010 Sep 14;75(11):946-7   [PMID:  20837961 ]
J Neurol. 2010 Nov;257(11):1943-5   [PMID:  20978904 ]

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