Document Detail


Aortic stiffness: an old concept for new insights into the pathophysiology of functional mitral regurgitation.
MedLine Citation:
PMID:  23064718     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Functional mitral regurgitation (FMR) is thought to be linked with ventricular afterload. However, the relation between aortic stiffness, which is a main determinant of ventricular afterload, and quantitatively assessed mitral regurgitation is unknown. A total of 175 patients (age 61 ± 13; 85 % male) with left ventricular (LV) systolic dysfunction were studied consecutively. Left ventricular volumes, ejection fraction, and LV outflow tract stroke volume were measured. Aortic pulse wave velocity (PWV), a known marker of aortic stiffness, was determined using Doppler flow recordings as the distance (d) traveled by the pulse wave, measured over the body surface as the distance between the two recording sites, divided by the time (t) taken by the pulse wave to travel from the descending aorta to the abdominal aorta. Mitral effective regurgitant orifice (ERO), regurgitant volume (RV), and fraction (RF) were measured using the proximal isovelocity surface area method. The mean PWV was 6.0 ± 3.5 m/s (range 2.6-25). PWV was significantly associated with ERO (r = 0.35; p < 0.0001), RV (r = 0.36; p < 0.0001) RF (p = 0.41; p < 0.0001). The association of PWV with each variable of mitral regurgitation was independent of LV volume, cardiac output, and systemic vascular resistance. Aortic stiffness is an important determinant of the severity of FMR. Aortic stiffness should be considered an important therapeutic target in patients with LV dysfunction in order to ameliorate both LV systolic and diastolic function and mitral regurgitation.
Authors:
Andrea Rossi; Stefano Bonapace; Mariantonietta Cicoira; Luca Conte; Anna Anselmi; Corrado Vassanelli
Related Documents :
3341178 - Reproducibility of quantitative two-dimensional echocardiography.
10558838 - A simple formula for predicting claw volume of cattle.
15172278 - Septal reshaping for exclusion of anteroseptal dyskinetic or akinetic areas.
2688978 - The interaction between diltiazem and left ventricular function after myocardial infarc...
10616998 - Myocardial recovery after mechanical support for acute myocarditis: is sustained recove...
8846418 - Bradykinin as an endogenous myocardial protective substance with particular reference t...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-13
Journal Detail:
Title:  Heart and vessels     Volume:  -     ISSN:  1615-2573     ISO Abbreviation:  Heart Vessels     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Sezione di Cardiologia, Dipartimento di Scienze Biomediche e Chirurgiche, Università di, Verona, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  MR findings of steatotic focal nodular hyperplasia and comparison with other fatty tumours.
Next Document:  Clinical characteristics and long-term outcome of acute myocarditis in children.