Document Detail

Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects.
MedLine Citation:
PMID:  15710784     Owner:  NLM     Status:  MEDLINE    
Aortic stiffness may predict progression to hypertension beyond classic risk factors. In a longitudinal study, we assessed the predictive value of aortic stiffness on future hypertension in nonhypertensive subjects with blood pressure (BP) <140/90. Aortic stiffness was determined by echocardiography at baseline in 2512 subjects. The follow-up time was 4 years. A stepwise increase in hypertension incidence occurred across the male and older participants: 3.8% of young female individuals, 11.5% of young male, 26.1% of old female, and 58.8% of old male subjects progressed to hypertension over 4 years. In multivariate analysis, aortic stain, distensibility, and stiffness index (beta) remained significantly associated with the progression to future hypertension after adjustment to classic risk factors in men and women and in young and old populations. This study provides the first direct evidence to our knowledge in a longitudinal study that aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive individuals.
John Dernellis; Maria Panaretou
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Publication Detail:
Type:  Journal Article     Date:  2005-02-14
Journal Detail:
Title:  Hypertension     Volume:  45     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-25     Completed Date:  2005-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-31     Citation Subset:  IM    
Department of Cardiology, Vostanion Hospital, Mytilini, Greece.
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MeSH Terms
Age Distribution
Aged, 80 and over
Aorta / physiopathology*,  ultrasonography
Follow-Up Studies
Hypertension / epidemiology,  etiology*
Longitudinal Studies
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Sex Distribution
Comment In:
Hypertension. 2005 Mar;45(3):349-51   [PMID:  15710783 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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