Document Detail

Aortic stiffness and calcification in men in a population-based international study.
MedLine Citation:
PMID:  22537531     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Aortic stiffness, a hallmark of vascular aging, is an independent risk factor of cardiovascular disease and all-cause mortality. The association of aortic stiffness with aortic calcification in middle-aged general population remains unknown although studies in patients with end-stage renal disease or elderly subjects suggest that aortic calcification is an important determinant of aortic stiffness. The goal of this study was to examine the association of aortic calcification and stiffness in multi-ethnic population-based samples of relatively young men.
METHODS: We examined the association in 906 men aged 40-49 (81 Black Americans, 276 Japanese Americans, 258 White Americans and 291 Koreans). Aortic stiffness was measured as carotid-femoral pulse wave velocity (cfPWV) using an automated waveform analyzer. Aortic calcification from aortic arch to iliac bifurcation was evaluated using electron-beam computed tomography.
RESULTS: Aortic calcium score was calculated and was categorized into four groups: zero (n=303), 1-100 (n=411), 101-300 (n=110), and 401+ (n=82). Aortic calcification category had a significant positive association with cfPWV after adjusting for age, race, and mean arterial pressure (mean (standard error) of cfPWV (cm/s) from the lowest to highest categories: 836 (10), 850 (9), 877 (17) and 941 (19), P for trend <0.001). The significant positive association remained after further adjusting for other cardiovascular risk factors. The significant positive association was also observed in each race group.
CONCLUSIONS: The results suggest that aortic calcification can be one mechanism for aortic stiffness and that the association of aortic calcification with stiffness starts as early as the 40s.
Akira Sekikawa; Chol Shin; J David Curb; Emma Barinas-Mitchell; Kamal Masaki; Aiman El-Saed; Todd B Seto; Rachel H Mackey; Jina Choo; Akira Fujiyoshi; Katsuyuki Miura; Daniel Edmundowicz; Lewis H Kuller; Hirotsugu Ueshima; Kim Sutton-Tyrrell
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-27
Journal Detail:
Title:  Atherosclerosis     Volume:  222     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-09-20     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.
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MeSH Terms
African Americans / statistics & numerical data*
Age Factors
Aorta / pathology*,  physiopathology
Aortic Diseases / ethnology*,  pathology,  physiopathology,  radiography
Aortography / methods
Asian Americans / statistics & numerical data*
Asian Continental Ancestry Group / statistics & numerical data*
Cross-Sectional Studies
European Continental Ancestry Group / statistics & numerical data*
Japan / epidemiology
Linear Models
Middle Aged
Pulsatile Flow
Republic of Korea / epidemiology
Risk Assessment
Risk Factors
Severity of Illness Index
Sex Factors
Tomography, X-Ray Computed
United States / epidemiology
Vascular Calcification / ethnology*,  physiopathology,  radiography
Grant Support

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