| Aortic stenosis five years after coronary artery bypass grafting in a young patient with homozygous familial hypercholesterolemia. | |
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MedLine Citation:
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PMID: 19301565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Homozygous familial hypercholesterolemia (FH) is an autosomal dominant disease caused by a mutation in the low-density lipoprotein (LDL) receptor. This mutation can lead to increased serum LDL, and subsequently to premature coronary artery disease. It may also lead to valvular and supravalvular aortic stenosis, these complications being cardinal in the natural course of the disease. The surgical treatment of aortic stenosis in patients with homozygous FH is accompanied by high risk, even in skillfu1 hands. Herein is presented the long-term follow up of a young patient with homozygous FH who underwent coronary artery bypass graft surgery at the age 14 years. Although the patient developed aortic stenosis five years later, neither the native coronary vessels nor grafted vessels underwent any atherosclerotic changes during this period. |
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Authors:
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Mohammad Hassan Nemati |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of heart valve disease Volume: 18 ISSN: 0966-8519 ISO Abbreviation: J. Heart Valve Dis. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312096 Medline TA: J Heart Valve Dis Country: England |
Other Details:
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Languages: eng Pagination: 125-7 Citation Subset: IM |
Affiliation:
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Cardiac Surgery Department, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. nemati_mhs@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aortic Valve / surgery Aortic Valve Stenosis / complications*, surgery Coronary Artery Bypass* Coronary Artery Disease / complications*, surgery Heart Valve Prosthesis Implantation Homozygote Humans Hyperlipoproteinemia Type II / complications*, genetics Male |
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