| Aortic size index enlargement is associated with central hemodynamics in essential hypertension. | |
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MedLine Citation:
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PMID: 20882032 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the association between brachial and central blood pressure (bBP and cBP) levels and aortic root dilatation (ARD) in essential hypertensive patients. A total of 190 untreated and treated essential hypertensive patients (mean age, 55 ± 11 years) were considered for this analysis. We measured pulsatile hemodynamics and the proximal aortic diameter directly using tonometry, ultrasound imaging (echocardiography) and Doppler. Ninety-one hypertensive patients had an ARD (defined as aortic size index (ASi)>2 cm/m(2)). Central hemodynamic variables were significantly associated with ASi. Patients with increased ASi were significantly older (60 ± 10 vs. 50 ± 11 years, P < 0.0001) and had higher levels of the augmentation index (AIx; 28 ± 10 vs. 21 ± 10 P < 0.0001), augmentation pressure (AP; 13 ± 6 vs. 8 ± 5 mm Hg, P < 0.0001), and central pulse pressure (cPP; 44 ± 10 vs. 39 ± 8 mm Hg, P<0.0001) compared with patients with normal ASi. In a logistic regression analysis, the AIx was the only significant predictor of ASi. In hypertensive patients, the AIx and cBP were associated with ARD, whereas the bBP was not. Patients with an increased ASi may lose part of the elastic properties of the aorta, demonstrating a strict correlation between ASi and central hemodynamic indexes, in particular, the cPP and AIx. |
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Authors:
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Alberto Milan; Francesco Tosello; Mimma Caserta; Diego Naso; Elisabetta Puglisi; Corrado Magnino; Chiara Comoglio; Franco Rabbia; Paolo Mulatero; Franco Veglio |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-30 |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 34 ISSN: 1348-4214 ISO Abbreviation: Hypertens. Res. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: England |
Other Details:
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Languages: eng Pagination: 126-32 Citation Subset: IM |
Affiliation:
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Department of Medicine and Experimental Oncology, Division of Internal Medicine, Hypertension Unit, University Hospital S Giovanni Battista, Torino, Italy. alberto.milan@unito.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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