Document Detail

Aortic root ectasia in patients with acromegaly: experience at a single center.
MedLine Citation:
PMID:  21521335     Owner:  NLM     Status:  Publisher    
Background:  Acromegaly is associated with increased cardiovascular mortality, and increased aortic root diameter has been recently described in the literature as a possible feature of acromegalic cardiomyopathy. Objective:  To assess the aortic root diameter and the prevalence of aortic ectasia in acromegalic patients. Patients and Methods:  This paper presents a transversal analysis of 42 acromegalic patients by Doppler echocardiogram and comparison with 42 age, sex, body surface area and hypertension matched controls. Results:  The mean aortic root diameter at the level of the aortic leaflets was increased in acromegalic patients when compared to controls (3.4±0.5 vs. 2.9±0.4 cm, respectively, p < 0.0001). The aortic root diameter was significantly greater in men than in women (3.6±0.6 cm vs. 3.2±0.4 cm, respectively, p=0.004), and the left ventricular mass index was positively correlated with the diameter of the aorta (r=0.37, p=0.01). Using a cut-off point ≥ 3.8 cm, an aortic ectasia prevalence of 26.1%vs. 2.3% was found in acromegalic patients and controls, respectively (p=0.002). Only acromegaly was associated with aortic ectasia (p=0.01). Conclusion:  The aortic root diameter was higher, and the prevalence of aortic ectasia was more common in acromegalic patients than in controls. In addition, only acromegalic disease was associated with aortic ectasia, suggesting the direct effects of GH and IGF-I excess on the cardiovascular system.
Alessandra Ferri Casini; Leonardo Vieira Neto; Rosita Fontes; Rodrigo Fraguas França; Sérgio Salles Xavier; Mônica Roberto Gadelha
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-18
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Endocrinology Unit - Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, Rio de Janeiro/Brazil Endocrinology Unit - Hospital da Lagoa, Rio de Janeiro/Brazil Diagnósticos da América - Medicina Diagnóstica, Rio de Janeiro/Brazil Cardio Diagnóstico - Espírito Santo/Brazil Cardiology Unit - Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, Rio de Janeiro/Brazil Endocrinology Unit - Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro/Brazil.
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