Document Detail

Aortic root dimensions among patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.
MedLine Citation:
PMID:  23347864     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to characterize aortic root dimensions of patients with aortic valve stenosis undergoing transcatheter aortic valve replacement (TAVR) and to evaluate sex differences.
BACKGROUND: The advent of TAVR makes a precise delineation of the aortic root anatomy mandatory and requires a profound anatomic understanding.
METHODS: Patients planned to undergo TAVR underwent screening imaging with use of a 64-slice or dual-source electrocardiogram-gated contrast-enhanced computed tomography. Anatomic dimensions were assessed at the level of the left ventricular outflow tract (LVOT), annulus, sinus of Valsalva, and ascending aorta.
RESULTS: The study population comprised 80 men and 97 women (age: 82 ± 6 years) with symptomatic severe aortic valve stenosis. Multislice computed tomography aortic root assessment revealed larger annular and LVOT dimensions in men than women (area annulus: 483.1 ± 75.6 mm(2) vs. 386.9 ± 58.5 mm(2), p = 0.0002; area LVOT: 478.2 ± 131.0 mm(2) vs. 374.0 ± 94.2 mm(2), p = 0.0024), whereas dimensions of the ascending aorta were comparable. Both LVOT and annulus were predominantly oval without sex differences, with a higher mean ellipticity index for the LVOT compared with the annulus (1.49 ± 0.2 vs. 1.29 ± 0.1); the ascending aorta was primarily circular (1.07 ± 0.1). Although similar in mean surface area, an area mismatch of annulus and LVOT of more than 10%, 20%, and 40% was detected in 42, 9, and 2 patients, respectively. The mean distance from annulus to the left coronary ostium was smaller than the mean distance of the right coronary ostium (14.4 ± 3.6 mm vs. 16.7 ± 3.6 mm), and distances were lower among women than men.
CONCLUSIONS: The aortic root has specific anatomic characteristics, which affect device design, selection, and clinical outcome in patients undergoing TAVR. Female sex is associated with smaller annular and LVOT but not aortic dimensions. The degree of ellipticity as well as a significant mismatch between annular and LVOT dimensions in selected patients deserve careful evaluation.
Lutz Buellesfeld; Stefan Stortecky; Bindu Kalesan; Steffen Gloekler; Ahmed A Khattab; Fabian Nietlispach; Valentina Delfine; Christoph Huber; Balthasar Eberle; Bernhard Meier; Peter Wenaweser; Stephan Windecker
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  6     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-07-09     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  72-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Aged, 80 and over
Aortic Valve / pathology*,  radiography
Aortic Valve Stenosis / pathology,  radiography,  therapy*
Cardiac Catheterization* / instrumentation
Cardiac-Gated Imaging Techniques
Chi-Square Distribution
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation / instrumentation,  methods*
Linear Models
Multidetector Computed Tomography
Patient Selection
Predictive Value of Tests
Prospective Studies
Prosthesis Design
Retrospective Studies
Severity of Illness Index
Sex Factors
Sinus of Valsalva / pathology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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