Document Detail

Aortic response to balloon injury in obese Zucker rats.
MedLine Citation:
PMID:  23043778     Owner:  NLM     Status:  MEDLINE    
The small diameter of the carotid artery is not compatible with the evaluation of clinically available endovascular devices in the carotid balloon-injury (BI) model. We developed an endovascular BI model in the rat descending aorta, whose size is compatible with available endovascular instruments. We also tested the hypothesis that neointima formation is enhanced in the aorta of obese Zucker rats (OZR) compared with lean Zucker rats (LZR). Left external carotid arteriotomies and BI of the thoracic and abdominal aorta were performed by using a balloon catheter. Aortograms and aortic pathology were examined at 2, 4, and 10 wk after BI. At 10 wk after BI, the abdominal aorta in OZR had narrowed 8.3% ± 1.1% relative to baseline compared with an expansion of 2.4% ± 2.2% in LZR. Simultaneously, the thoracic aorta had expanded 9.5% ± 4.3% in LZR compared with stenosis of 2.8% ± 1.6% in OZR. Calculation of the intimal:medial thickness ratio revealed significantly increased neointimal formation in the OZR descending aorta compared with that in LNR. In conclusion, this minimally invasive BI model involving the rat descending aorta is compatible with available endovascular instruments. The descending aorta of OZR demonstrates enhanced neointimal formation and constrictive vascular remodeling after BI.
Ludwig D Orozco; Huiling Liu; Betty B Chen; Razvan F Buciuc; Jonathan D Fratkin; Juan C Pisarello; Eddie Perkins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative medicine     Volume:  62     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-02-27     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-70     Citation Subset:  IM    
Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
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MeSH Terms
Analysis of Variance
Angioplasty, Balloon / adverse effects*
Aorta / injuries*,  physiopathology*
Endovascular Procedures / instrumentation*
Models, Animal*
Neointima / pathology*
Obesity / physiopathology*
Rats, Zucker
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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