Document Detail

Aortic pulse wave velocity and carotid-femoral pulse wave velocity: similarities and discrepancies.
MedLine Citation:
PMID:  18344619     Owner:  NLM     Status:  MEDLINE    
The objectives of this study were to determine the relationship between carotid-femoral (cfPWV) and aortic pulse wave velocity (aPWV) and to compare their modulators and association with coronary artery disease (CAD). We studied 107 consecutive patients (68 men) with a mean age of 60.49+/-8.31 years who had stable angina and had been referred for coronary angiography. cfPWV and aPWV were measured simultaneously during cardiac catheterization using the Complior device and aortic pressure waveform recordings, respectively. Based on the presence or absence of significant coronary artery stenosis (CAS) patients were subdivided into a CAS+ or CAS- group. The mean values of cfPWV and aPWV were 10.65+/-2.29 m/s and 8.78+/-2.24 m/s, respectively. They were significantly higher in the CAS+ (n=71) compared with the CAS- (n=36) group and predicted significant CAS independently of cardiovascular risk factors and mean or systolic aortic blood pressure. aPWV and cfPWV were significantly correlated (r=0.70; p<0.001) but the degree of correlation differed significantly (p<0.03) between the CAS+ (r=0.74, p<0.001) and CAS- group (r=0.46, p=0.003). Age and mean aortic blood pressure were independent predictors for aPWV as well as cfPWV. In the receiver operating characteristic (ROC) analysis, aPWV and cfPWV had similar accuracy in identification of significant CAS (AUC [area under the ROC curve]=0.76 and 0.69, respectively; p=0.13). However, neither cfPWV nor aPWV was effective at differentiating the extent of CAD. In conclusion, aPWV and cfPWV are highly correlated parameters with similar determinants and comparable accuracy in predicting significant CAS. The strength of correlation between these two indices differed significantly between subjects with and those without CAS.
Piotr Podolec; Grzegorz Kopeć; Jakub Podolec; Piotr Wilkołek; Marek Krochin; Paweł Rubiś; Marcin Cwynar; Tomasz Grodzicki; Krzysztof Zmudka; Wiesława Tracz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  30     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1151-8     Citation Subset:  IM    
Department of Cardiac and Vascular Diseases, Jagiellonian University, Collegium Medicum, Kraków, Poland.
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MeSH Terms
Aorta / physiopathology*
Blood Pressure / physiology
Carotid Arteries / physiopathology*
Coronary Artery Disease / diagnosis,  etiology,  physiopathology
Femoral Artery / physiopathology*
Heart Rate / physiology*
Middle Aged
Predictive Value of Tests
Regional Blood Flow / physiology
Regression Analysis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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