| Aortic pulse pressure and extent of coronary artery disease in percutaneous transluminal coronary angioplasty candidates. | |
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MedLine Citation:
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PMID: 12160188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pulse pressure and aortic stiffness are both predictors of coronary artery disease. Whether these parameters are directly related to coronary structural alterations has never been studied. METHODS: From September 1999 to September 2000, the following data were collected from 99 eligible patients: invasive intra-aortic systolic and diastolic blood pressures (BP), extent of coronary artery disease, cardiovascular risk factors, and the incidence of angiographically documented restenosis after coronary angioplasty. RESULTS: In the study population, independent determinants of aortic pulse pressure were age, gender, aortic mean BP, heart rate, and extent of coronary artery disease (r2 = 0.57, P < .0001). In univariate analysis, invasive aortic, but not noninvasive brachial, mean pressure (P = .017) and pulse pressure (P = .027) were significantly associated to the extent of coronary artery disease. In a multiple regression analysis, only male gender (P = .013) and the level of aortic pulse pressure (P = .023) were independently associated with the extent of coronary heart disease. Restenosis was angiographically documented in 11 patients (11%). There was a borderline significant association of restenosis to aortic mean BP (P = .05) and to a past history of multiple previous angioplasties (P = .03). CONCLUSIONS: In this study, aortic pulse pressure was a significant risk factor for the extent of coronary artery disease. There was only a borderline significant association of restenosis to the steady, but not pulsatile, component of aortic BP in the stent era. |
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Authors:
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François Philippe; Elie Chemaly; Jacques Blacher; Jean-Jacques Mourad; Alain Dibie; Fabrice Larrazet; François Laborde; Michel E Safar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hypertension Volume: 15 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-05 Completed Date: 2003-01-29 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 672-7 Citation Subset: IM |
Affiliation:
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Département de cardiologie, Institut Mutualiste Montsouris, Paris France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Angioplasty, Transluminal, Percutaneous Coronary* Aorta / physiopathology Blood Pressure* Cohort Studies Coronary Artery Disease / etiology, physiopathology* Coronary Restenosis / etiology Female France Humans Male Middle Aged Regression Analysis Risk Factors Vascular Resistance* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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