| Aortic pulse pressure and atherosclerotic structural alterations of coronary arteries. | |
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MedLine Citation:
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PMID: 19440211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulse pressure (PP) is an independent predictor of myocardial infarction, mainly above 50 years of age. In subjects with preserved ejection fraction (EF), aortic PP predicts the severity of coronary atherosclerosis. Comparable findings in subjects with reduced EF have not been evaluated. In 1337 subjects with severe coronary ischaemic disease, intra-aortic and brachial blood pressures were measured together with EF and coronary angiography to evaluate cardiac function, the presence of coronary stenosis and/or occlusions or calcifications. The presence (odds ratio+/-95% CI) of coronary calcification was marginally but not significantly associated (P=0.06) to increased aortic PP (1.32 (0.97-1.80)), whereas that of coronary occlusion was significantly associated (P<0.01) with decreased aortic PP (0.62 (0.42-0.91)), even after adjustment to EF and heart rate. Increased aortic PP did not correlate with stenosis number. No comparable predictive value was observed using intra-aortic or non-invasive brachial systolic blood pressure (SBP) or diastolic blood pressure (DBP). In high cardiovascular risk populations, even in the presence of reduced EF and high heart rate, intra-aortic PP, but not SBP or DBP, is a significant predictor of coronary occlusions and possibly calcifications, but not stenosis. |
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Authors:
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J-J Mourad; N Danchin; A Rudnichi; M Lopez-Sublet; S Le Jeune; M E Safar; |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of human hypertension Volume: 24 ISSN: 1476-5527 ISO Abbreviation: J Hum Hypertens Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 51-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Avicenne Hospital AP-HP, Bobigny, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aorta / physiopathology* Blood Pressure* Calcinosis / physiopathology Coronary Artery Disease / pathology, physiopathology* Female Humans Logistic Models Male Middle Aged Stroke Volume |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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