| Aortic pulse pressure and aortic pulsatility are associated with angiographic coronary artery disease in women. | |
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MedLine Citation:
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PMID: 16257875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Studies indicated that both aortic pulse pressure (PP) and aortic pulsatility are independently associated with angiographic coronary artery disease (CAD). However, most of these studies included a majority of male subjects, and women were underrepresented. OBJECTIVE: We investigated the relation of aortic PP and aortic pulsatility derived from invasively measured ascending aortic pressure waveform and presence of angiographic CAD in women undergoing diagnostic coronary angiography. METHODS AND RESULTS: From September 2003 to April 2004, 262 unselected female subjects undergoing first cardiac catheterization were consecutively included in the study. Systolic, diastolic and mean pressure waveforms of the ascending aorta were measured during cardiac catheterization with a fluid-filled system. Aortic pulsatility was estimated as the ratio of aortic PP to mean pressure. Angiographic CAD was detected in 175 (67%) patients. In multiple-adjusted logistic regression, both aortic PP and aortic pulsatility were significantly associated with the presence of CAD (for a 10-mmHg increase in PP: odds ratio [OR] = 1.3, 95% confidence interval [CI] = 1.1-1.76; for a 0.1 increase in aortic pulsatility: OR = 1.8, 95% CI = 1.3-2.4). When patients were divided into tertiles according to the level of aortic pulsatility, it was noted that multiple-adjusted OR of presence CAD was 2.2 (95% CI = 1.1-4.4) for the middle tertile of the aortic pulsatility level and 5.9 (95% CI = 2.7-12.8) for the highest tertile of the aortic pulsatility level compared with the lowest tertile. CONCLUSION: In female subjects referred to coronary angiography, ascending aorta PP and aortic pulsatility are significantly associated with the presence of angiographic CAD and these associations are independent of age and other cardiovascular risk factors. |
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Authors:
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Yesim Guray; Umit Guray; Hakan Altay; Serkan Cay; Mehmet Birhan Yilmaz; Halil Lutfu Kisacik; Sule Korkmaz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure Volume: 14 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2005-12-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: Norway |
Other Details:
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Languages: eng Pagination: 293-7 Citation Subset: IM |
Affiliation:
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Yuksek Ihtisas Hospital, Department of Cardiology, Ankara, Turkey. yesim_guray@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / therapeutic use Aorta / physiopathology* Blood Pressure* Causality Coronary Angiography Coronary Artery Disease / diagnosis, epidemiology*, physiopathology* Female Humans Middle Aged Pulsatile Flow* Regression Analysis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
| Comments/Corrections | |
Comment In:
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Blood Press. 2005;14(5):260-1
[PMID:
16257869
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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