Document Detail


Aortic pressure augmentation as a marker of cardiovascular risk in obstructive sleep apnea syndrome.
MedLine Citation:
PMID:  18716358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obstructive sleep apnea syndrome (OSAS) is associated with increases in cardiovascular morbidity and mortality. Vascular changes in individuals with OSAS have not been fully elucidated, however. The possible impact of OSAS on the extent of aortic pressure augmentation (AG), an indicator of cardiovascular risk, was investigated. Forty-five consecutive male patients aged 35 to 78 years (56.0+/-9.6 years) who were referred to the sleep clinic of Nagoya University Hospital for screening and treatment of OSAS and 71 age-matched healthy men were enrolled in the study. AG was derived from the pressure waveform measured at the radial artery by applanation tonometry. The number of apnea and hypopnea episodes per hour (apnea-hypopnea index [AHI]) was determined by standard polysomnography. AG was significantly greater in OSAS patients than in controls (9.0+/-4.1 vs. 6.4+/-3.4 mmHg, p<0.001), and it was significantly reduced in 19 OSAS patients treated with continuous positive airway pressure. AG was also significantly correlated with the AHI (r=0.562, p<0.001) and age (r=0.356, p=0.016) but not with the serum concentrations of low and high density lipoprotein-cholesterol, triglyceride, or glycosylated hemoglobin. Stepwise multiple regression analysis revealed that the AHI was the most significant contributing factor to the increased AG in OSAS patients (beta=0.109, r=0.530, p<0.001). OSAS may thus have an adverse effect on vascular function that can be ameliorated by appropriate treatment.
Authors:
Akiko Noda; Seiichi Nakata; Hiroshi Fukatsu; Yoshinari Yasuda; Etsuko Miyao; Seiko Miyata; Fumihiko Yasuma; Toyoaki Murohara; Mitsuhiro Yokota; Yasuo Koike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  31     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1109-14     Citation Subset:  IM    
Affiliation:
Nagoya University School of Health Sciences, Higashi-kuNagoya, Japan. a-noda@met.nagoya-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aorta / physiopathology*
Biological Markers
Blood Pressure*
Cardiovascular Diseases / etiology*
Continuous Positive Airway Pressure
Hemoglobin A, Glycosylated / analysis
Humans
Male
Middle Aged
Regression Analysis
Sleep Apnea, Obstructive / complications*,  physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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