Document Detail

Aortic lesions in aspergillosis: histopathological study of two autopsy cases.
MedLine Citation:
PMID:  11764384     Owner:  NLM     Status:  MEDLINE    
The involvement of the aorta in aspergillosis is relatively rare, and its histopathological features have not been described in detail. In two autopsy cases of invasive aspergillosis in immunologically compromised patients with hematological disorders, the aspergillotic lesions of the aorta showed different characteristic histopathological features depending on the three layers of aortic wall. Intimal lesions were formations of the mural thrombus composed of aggregates of numerous fungal hyphae arranged perpendicularly to the aortic wall. In the media, smooth muscle cells were completely necrotic (anemic infarct of the media), while the framework of elastic fibers was well preserved, with only a few fungal hyphae detected. In the adventitia, an intense, partly granulomatous chronic inflammatory change with fibrosis was observed in association with mycotic embolic occlusion of the vasa vasorum. These histopathological changes were considered to represent one of the typical tissue reaction patterns in the wall of an elastic artery in aspergillosis.
M Shintaku; A Sangawa; A Yonezawa; K Nasu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  439     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-14     Completed Date:  2002-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  640-4     Citation Subset:  IM    
Department of Pathology, Osaka Red Cross Hospital, Tennoji, Japan.
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MeSH Terms
Aorta, Thoracic / microbiology,  pathology*
Aortic Diseases / microbiology,  pathology*
Aspergillosis / complications,  pathology*
Fatal Outcome
Immunocompromised Host
Middle Aged

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