| Aortic involvement in giant cell arteritis. | |
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MedLine Citation:
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PMID: 20149900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Giant cell arteritis (GCA) is a primary large-vessel vasculitis predominantly seen in the elderly that preferentially involves the external carotid artery and its branches. However, inflammation of the aorta and its branches occurs in a subset of patients although symptoms of aortic involvement may appear years after the initial diagnosis of GCA. Therefore, aortic involvement has probably been underestimated and its incidence may be more frequent than suspected. Systematic evaluation of patients with imaging techniques such as magnetic resonance imaging angiography (MRA) and positron emission tomography (PET) may reveal that the clinical impact of extracranial involvement by GCA may be more relevant than previously thought. Regarding the histopathology, there are some similarities between chronic periaortitis (including idiopathic retroperitoneal fibrosis, inflammatory abdominal aortic aneurysms and perianeurysmal retroperitoneal fibrosis), idiopathic aortitis, and GCA, suggesting that all these illnesses probably share common pathological mechanisms. Inflammatory aortitis can arise in different clinical settings been idiopathic aortitis more frequent than expected in surgical specimens of aortic aneurysm surgeries in the general population. In the setting of GCA an early diagnosis of aortic involvement is mandatory in order to perform a treatment capable of avoiding the chronic and acute complications associated with an elevated mortality [1, 2]. |
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Authors:
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F Martínez-Valle; R Solans-Laqué; J Bosch-Gil; M Vilardell-Tarrés |
Publication Detail:
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Type: Journal Article; Review Date: 2010-02-08 |
Journal Detail:
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Title: Autoimmunity reviews Volume: 9 ISSN: 1873-0183 ISO Abbreviation: Autoimmun Rev Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101128967 Medline TA: Autoimmun Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 521-4 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Internal Medicine Department, Vall d'Hebron University Hospital, Barcelona, Spain. ferranmartinezvalle@gmail.com <ferranmartinezvalle@gmail.com> |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Aortic Aneurysm, Abdominal / diagnosis*, epidemiology, etiology, immunology* Arteritis* Carotid Artery, External / immunology Diagnostic Imaging Early Diagnosis Giant Cell Arteritis / complications, diagnosis*, epidemiology, immunology* Humans Incidence Prevalence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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