| Aortic input impedance in man: acute response to vasodilator drugs. | |
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MedLine Citation:
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PMID: 7226476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 18 patients who underwent coronary arteriography, aortic velocity and pressure data were obtained during a control state and during either isoproterenol infusion at 1, 2 and 3 micrograms/min or graded nitroprusside infusion (average peak dose 60 micrograms/min). Impedance moduli and phase angles were derived to 10 Hz for controls states, isoproterenol at 2 micrograms/min, and at peak nitroprusside effect. Averaged control data included a mean resistance of 1460 dyn-sec-cm-5 and a characteristic impedance of 88 dyn-sec-cm-5 The characteristic impedance did not correlate with age (r = 0.21), coronary artery disease score (r = 0.17) or mean aortic pressure (r = -0.01). In 11 patients, isoproterenol induced a 38% reduction in mean resistance and a 10% reduction in mean aortic pressure. There was slight reduction in characteristic impedance and phase angles became less negative, to 2 Hz. In seven patients, nitroprusside induced a 38% reduction in mean resistance and a 22% reduction in mean aortic pressure. Impedance moduli decreased to 1.8 Hz and phase angles became less negative, to 3 Hz. Based on the different cardiovascular actions of these two drugs, the data suggest that vasodilators do not induce significant changes in the aortic impedance spectrum when not associated with a decrease in mean aortic pressure. |
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Authors:
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W Gundel; G Cherry; B Rajagopalan; L B Tan; G Lee; D Schultz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 63 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1305-14 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angina Pectoris / drug therapy Aorta / physiopathology* Blood Pressure / drug effects Cardiography, Impedance Female Ferricyanides / therapeutic use* Heart Rate / drug effects Hemodynamics / drug effects Humans Isoproterenol / therapeutic use* Male Middle Aged Nitroprusside / therapeutic use* Stroke Volume / drug effects Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Ferricyanides; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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