Document Detail


Aortic impedance in Little mice.
MedLine Citation:
PMID:  19162929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Little dwarf mouse lives 30% longer than its age-matched wild-type (WT) mouse. We determined aortic input impedance in 21 (8 Little, 13 WT) 4 month-old mice. Modulus of impedance was calculated from the Fourier transformed aortic pressure (P) and average luminal flow velocity (V(avg)) as |Z(i)| = |P|/|V(avg)|. Characteristic impedance was estimated by averaging the 2(nd)-10(th) harmonic of the impedance moduli. We found the impedance modulus |Z(i)| to be similar in the 2 groups (WT vs. Little; mean+/-SE) - peripheral resistance (10597+/-654 vs. 12932+/-1433 dyne-s/cm(3)), modulus at first harmonic (Z(1): 740+/-56 vs. 902+/-105 dyne-s/cm(3)), and characteristic impedance (Z(c): 441+/-34 vs. 470+/-60 dyne-s/cm(3)). Also, mean aortic velocity (20.1+/-1.1 vs. 16.5+/-1.8 cm/s) and mean aortic blood pressure (81.1+/-3.9 vs. 75.9+/-5.9 mmHg) were similar between the two groups. Impedance at low frequencies was slightly higher in the dwarf mice which may be due to the diminished systolic function as indicated by significant reduction in peak aortic velocity (84.0+/-3.2 vs. 70.1+/-1.2 cm/s, p<<0.01). Although modestly higher, the overall impedance in Little mice was similar to that in WT mice. This indicates that left ventricular (LV) afterload may not significantly be altered in Little mice.
Authors:
Anilkumar K Reddy; George E Taffet; Craig J Hartley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference     Volume:  2008     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2008  
Date Detail:
Created Date:  2009-02-16     Completed Date:  2009-05-05     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1397-8     Citation Subset:  IM    
Affiliation:
Sections of Cardiovascular Sciences&Geriatrics, Dept. of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. areddy@bcm.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / physiology*
Fourier Analysis
Heart Ventricles
Mice
Mice, Mutant Strains
Pulsatile Flow / physiology*
Species Specificity
Vascular Resistance / physiology*
Ventricular Function / physiology*
Grant Support
ID/Acronym/Agency:
AG17899/AG/NIA NIH HHS; HL073041/HL/NHLBI NIH HHS; HL22512/HL/NHLBI NIH HHS; K25 HL073041-03/HL/NHLBI NIH HHS; R01 HL022512/HL/NHLBI NIH HHS; R01 HL022512-32A1/HL/NHLBI NIH HHS
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