Document Detail

Aortic-iliac thrombosis in horses.
MedLine Citation:
PMID:  4002537     Owner:  NLM     Status:  MEDLINE    
Vascular obstruction of the hindlimbs was diagnosed clinically in 15 horses, and was characterized at necropsy in eight of those horses. The condition was identified as an incidental post mortem finding in two additional horses. The principal clinical signs in affected horses were progressive exercise intolerance and hind-leg lameness. At post mortem the oldest lesions were located at the aortic quadrifurcation and in the distal portions of the femoral and internal iliac arteries, and consisted of partially or completely occlusive masses of well-organized and well-vascularized fibrous tissue, occasionally containing hemorrhagic or degenerate areas. Proximal to these organized masses, large unorganized thrombi were often present. In the region of the occlusive masses, the tunica intima was obliterated, except for the internal elastic lamina which usually remained intact. The tunica media was largely unaffected, except for ischemic necrosis of the media in greatly distended arteries or under thick plaques. The pathogenesis of the lesions is unresolved. The lesions may result from organization of strongyle-related thromboemboli or the inciting cause may be progressive enlargement and organization of spontaneously developing fibrous intimal plaques. Hypercoagulability of the blood may have contributed to thrombosis in one mare with the nephrotic syndrome. Routine examination of the aortic quadrifurcation and its major branches is recommended in order that subclinical changes may be detected and the natural history of the lesion elucidated.
M G Maxie; P W Physick-Sheard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  22     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-07-17     Completed Date:  1985-07-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  238-49     Citation Subset:  IM    
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MeSH Terms
Aorta / pathology
Aortic Diseases / pathology,  veterinary*
Horse Diseases / pathology*
Iliac Artery* / pathology
Lameness, Animal / etiology
Strongyle Infections, Equine / pathology
Thrombosis / pathology,  veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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