Document Detail

Aortic function quantified: the heart's essential cushion.
MedLine Citation:
PMID:  22936729     Owner:  NLM     Status:  MEDLINE    
Arterial compliance is mainly determined by the elasticity of proximal large-conduit arteries of which the aorta is the largest contributor. Compliance forms an important part of the cardiac load and plays a role in organ (especially coronary) perfusion. To follow local changes in aortic compliance, as in aging, noninvasive determination of compliance distribution would be of great value. Our goal is to determine regional aortic compliance noninvasively in the human. In seven healthy individuals at six locations, aortic blood flow and systolic/diastolic area (ΔA) was measured with MRI. Simultaneously brachial pulse pressure (ΔP) was measured with standard cuff. With a transfer function we derived ΔP at the same aortic locations as the MRI measurements. Regional aortic compliance was calculated with two approaches, the pulse pressure method, and local area compliance (ΔA/ΔP) times segment length, called area compliance method. For comparison, pulse wave velocity (PWV) from local flows at two locations was determined, and compliance was derived from PWV. Both approaches show that compliance is largest in the proximal aorta and decreases toward the distal aorta. Similar results were found with PWV-derived compliance. Of total arterial compliance, ascending to distal arch (segments 1-3) contributes 40% (of which 15% is in head and arms), descending aorta (segments 4 and 5) 25%, and "hip, pelvic and leg arteries" 20%. Pulse pressure method includes compliance of side branches and is therefore larger than the area compliance method. Regional aortic compliance can be obtained noninvasively. Therefore, this technique allows following changes in local compliance with age and cardiovascular diseases.
Nabil Saouti; J Tim Marcus; Anton Vonk Noordegraaf; Nico Westerhof
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-30
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  2013-06-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1285-91     Citation Subset:  IM    
Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands.
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MeSH Terms
Aging / physiology
Aorta / physiology*
Blood Pressure / physiology*
Cardiovascular Diseases / physiopathology
Compliance / physiology
Diastole / physiology
Heart / physiology*
Magnetic Resonance Imaging / methods
Pulse Wave Analysis / methods
Regional Blood Flow / physiology
Systole / physiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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