| Aortic function: the heart's essential cushion. | |
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MedLine Citation:
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PMID: 22936729 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Arterial compliance is mainly determined by the elasticity of proximal large conduit arteries of which the aorta is the largest contributor. Compliance forms an important part of the cardiac load and plays a role in organ (especially coronary) perfusion. To follow local changes in aortic compliance, as in aging, noninvasive determination of compliance distribution would be of great value. Our goal is to determine regional aortic compliance non-invasively in the human. In 7 healthy individuals at 6 locations aortic blood flow and systolic/diastolic area (A) was measured with MRI. Simultaneously brachial Pulse Pressure (P) was measured with standard cuff. With a transfer function we derived P at the same aortic locations as the MRI measurements. Regional aortic compliance was calculated with two approaches, the pulse pressure method (PPM), and local area compliance (ΔA/ΔP) times segment length, called area compliance method (ACM). For comparison Pulse Wave Velocity (PWV) from local flows at two locations was determined, and compliance derived from PWV. Both approaches show that compliance is largest in the proximal aorta and decreases towards the distal aorta. Similar results were found with PWV derived compliance. Of total arterial compliance, ascending to distal arch (segments 1-3) contributes 40% (of which 15% in head and arms); descending aorta (segments 4&5) 25%; and "hip, pelvic and leg arteries" 20%. PPM includes compliance of side branches and is therefore larger than the ACM. Regional aortic compliance can be obtained non-invasively. Therefore this technique allows following changes in local compliance with age and cardiovascular diseases. |
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Authors:
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Nabil Saouti; J Tim Marcus; Anton Vonk-Noordegraaf; Nico Westerhof |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-30 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1VU University medical center, Amsterdam. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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