| Aortic and extracranial large vessel giant cell arteritis: a review of 72 cases with histopathologic documentation. | |
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MedLine Citation:
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PMID: 7667646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Giant cell arteritis (GCA) is closely identified with the temporal arteritis-polymyalgia rheumatica syndrome of the elderly. It is also a systemic disease that can cripple and kill. Up to 15% of patients with temporal arteritis may have angiographic evidence of extracranial GCA, and aortic insufficiency, ruptured aortic aneurysm, aortic dissection, stroke, or myocardial infarction may be the initial manifestation of systemic GCA. A review of 72 cases of aortic and extracranial GCA, all with histopathologic verification of the disease, revealed that 25% of patients with aortic and extracranial large-vessel GCA had asymptomatic temporal arteritis; the ascending aorta and aortic arch were most frequently involved (39%), followed by the subclavian and axillary arteries (26%), and the femoropopliteal arteries (18%). Nine patients (12.5%) underwent an upper or lower limb amputation. Of the 18 patients whose death was directly attributable to extracranial GCA the causes were ruptured aortic aneurysm (6), aortic dissection (6), stroke (3), and myocardial infarction (3). The findings of these 72 cases caution against attributing all aortic and large-vessel arterial disease in the elderly to atherosclerosis and emphasize that timely surgical intervention may be necessary for life-saving and limb-salvage in patients with aortic and extracranial GCA. |
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Authors:
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J T Lie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in arthritis and rheumatism Volume: 24 ISSN: 0049-0172 ISO Abbreviation: Semin. Arthritis Rheum. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-10-12 Completed Date: 1995-10-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 422-31 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of California Davis School of Medicine, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aneurysm, Dissecting / etiology, mortality Aortic Aneurysm / etiology, mortality Aortic Diseases / pathology, radiography Female Femoral Artery Giant Cell Arteritis / complications, pathology*, radiography Humans Male Middle Aged Popliteal Artery Subclavian Artery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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