Document Detail

Aortic elastic properties and left ventricular diastolic function in white-coat hypertensive individuals.
MedLine Citation:
PMID:  16810029     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Although white-coat hypertension may be present in 25% or more of hypertensive individuals, its prognostic significance and predisposition to end organ damage is unknown. To evaluate whether white-coat hypertension is associated with end organ damage, we compared prognostically relevant measures of target-organ damage among 35 individuals with white-coat hypertension and age and sex-matched groups of sustained hypertension and normotensive individuals classified by clinical and 24-h ambulatory blood pressures. METHODS: We evaluated left ventricular diastolic function and aortic elastic properties of 35 individuals with white-coat hypertension, 50 patients with sustained hypertension, and 35 normotensive healthy volunteers using transthoracic Doppler echocardiography. None of the study participants with sustained hypertension and white-coat hypertension, who were newly diagnosed and never treated, had any systemic disease or coronary risk factor except hypertension. RESULTS: Age, sex, and body mass indexes were similar among the three groups. Left ventricular diastolic function was more significantly impaired in the sustained hypertension and white-coat hypertension groups than in the control group, but it was not significantly different between the white-coat hypertension and sustained hypertension groups. Aortic distensibility was significantly lower, and aortic stiffness index was significantly higher in the sustained hypertension group than in the white-coat hypertension and control groups. Furthermore, aortic elastic properties were slightly impaired in the white-coat hypertension group compared with those in the control group. We also found a significant correlation between aortic elastic properties and left ventricular diastolic function. CONCLUSIONS: White-coat hypertension may alter left ventricular diastolic function and aortic elastic properties. These alterations, however, might not be as remarkable as those caused by sustained hypertension. In this respect, individuals with white-coat hypertension are not at such a risk for end organ damage as patients with sustained hypertension.
Dogan Erdogan; Mustafa Caliskan; Hakan Gullu; Ibrahim Yildirim; Ismail Ozer; Aliseydi Ozgul; Haldun Muderrisoglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure monitoring     Volume:  11     ISSN:  1359-5237     ISO Abbreviation:  Blood Press Monit     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-06-30     Completed Date:  2006-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606438     Medline TA:  Blood Press Monit     Country:  England    
Other Details:
Languages:  eng     Pagination:  191-8     Citation Subset:  IM    
Cardiology Department, Konya Teaching and Medical Research Center, Baskent University, Konya, Turkey.
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MeSH Terms
Aorta / physiology*
Blood Pressure Monitoring, Ambulatory
Echocardiography, Doppler
Hypertension / physiopathology*,  psychology*
Middle Aged
Observer Variation
Reproducibility of Results
Ventricular Function, Left / physiology*

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