| Aortic elastic properties in nonalcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 20414104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent studies have shown that patients with nonalcoholic fatty liver disease (NAFLD) have an increased risk of developing cardiovascular disease. Aortic stiffness, an early marker of arteriosclerosis, is associated with cardiovascular mortality. In this study, the aortic elastic properties of nondiabetic, normotensive NAFLD patients were evaluated. METHODS: Thirty-five patients with NAFLD and 30 age-matched and sex-matched healthy controls were enrolled. Aortic distensibility, aortic strain, aortic stiffness index (ASI), left ventricular mass index (LVMI), homeostasis model assessment of insulin resistance (HOMA-IR) and fasting lipid parameters were assessed in both the groups. RESULTS: ASI was higher in NAFLD patients (7.1+/-2.0) than in the control group (3.8+/-1.0) (P<0.01). Aortic distensibility and aortic strain were also significantly decreased in NAFLD patients as compared with the control group (2.9+/-0.7 cm/dyn vs. 6.3+/-2.4 cm/dyn, P<0.0001 and 7.1+/-1.7 vs. 14.5+/-4.0, P<0.0001, respectively). Although ASI was significantly correlated with age, HOMA-IR, waist circumference, body mass index and LVMI, a stepwise multiple linear regression analysis showed that HOMA-IR and LVMI were the only variables associated with ASI index [(standardized beta coefficient= 0.41, P=0.004, overall R=0.17) and (standardized beta coefficient=0.31, P=0.02, overall R=0.10), respectively]. CONCLUSION: Our data suggest that aortic elasticity is significantly impaired and is also associated with insulin resistance and LVMI in NAFLD patients, which may contribute to the relationship between NAFLD and the increased risk of cardiovascular disease among these patients. |
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Authors:
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Hakan Fotbolcu; Tolga Yakar; Dursun Duman; Kivilcim Ozden; Tansu Karaahmet; Kürşat Tigen; Unal Kurtoglu; Ismet Dindar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure monitoring Volume: 15 ISSN: 1473-5725 ISO Abbreviation: Blood Press Monit Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-08-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606438 Medline TA: Blood Press Monit Country: England |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
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Beytepe Military Hospital, Ankara, Turkey. hakan_fotbolcu@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aorta
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physiopathology* Cardiovascular Diseases / etiology Elasticity Fatty Liver / pathology, physiopathology* Humans Insulin Resistance Risk Vascular Resistance* Ventricular Dysfunction, Left / pathology, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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