Document Detail


Aortic and coronary calcifications in Takayasu arteritis.
MedLine Citation:
PMID:  23351614     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Atherosclerosis is well recognized in Takayasu arteritis (TAK) and the associated plaques tend to be more common in areas of arteritis. We now report arterial wall calcification in a large group of TAK patients and controls. We hypothesized that the degree of coronary artery calcification would point to a systemic effect of inflammation while that in the thoracic aorta more of local inflammation. METHODS: A total of 47 patients with TAK, 43 patients with SLE and 70 healthy controls (HC) were studied. The presence of coronary artery and thoracic aorta calcifications (ToAC) was investigated by multi-detector computed tomography (MDCT). Atherosclerotic plaques in the carotid arteries were screened using B mode ultrasound. RESULTS: The frequency of coronary artery calcification was significantly increased among patients with SLE as compared to the healthy controls while the increase in TAK did not reach statistical significance. There were more TAK patients with ToAC among the TAK as compared to the SLE patients [21/47 (45%) vs 10/43 (23%), P = 0.033]. In addition, a circumferential type of calcification, vs a punctuate or linear type, was the more common type in 67% of patients with TAK whereas only the linear or punctuate type was seen in SLE patients and HC. SLE and TAK patients were found to have increased risk for carotid artery plaques. Among TAK patients, coronary artery calcification, ToAC and carotid artery plaques tend to be at sites of primary vasculitic involvement. CONCLUSIONS: There is increased atherosclerosis in TAK and SLE. Vessel wall inflammation seems to be also important in the atherosclerosis associated with TAK.
Authors:
Emire Seyahi; Ayca Ucgul; Deniz Cebi Olgun; Serdal Ugurlu; Canan Akman; Onur Tutar; Sebahattin Yurdakul; Hasan Yazici
Related Documents :
23864534 - Is the treatment of the small saphenous veins with foam sclerotherapy at risk of deep v...
24928674 - Long-term results of neomedia sinus valsalva repair in 489 patients with type a aortic ...
24147244 - Fetal heterotaxy with tricuspid atresia, pulmonary atresia, and isomerism of the right ...
25007904 - More great saphenous vein valves - less varicose veins?
14605114 - Endovascular treatment of a wide-neck renal artery bifurcation aneurysm.
23864534 - Is the treatment of the small saphenous veins with foam sclerotherapy at risk of deep v...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  -     ISSN:  1532-866X     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey. Electronic address: eseyahi@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function...
Next Document:  The effect of physical activity and motivation on function in ankylosing spondylitis: A cohort study...