Document Detail

Aortic, but not brachial blood pressure category enhances the ability to identify target organ changes in normotensives.
MedLine Citation:
PMID:  23552129     Owner:  NLM     Status:  Publisher    
AIMS:: We sought to determine whether within normal/high-normal blood pressure (BP) ranges (120-139/80-89 mmHg), aortic BP may further refine BP-related cardiovascular risk assessment, as determined from target organ changes. METHODS:: In 1169 participants from a community sample of African ancestry, 319 (27%) of whom had a normal/high-normal BP, aortic BP was determined using radial applanation tonometry and SphygmoCor software, and target organ changes assessed from carotid-femoral pulse wave velocity (PWV) (n = 1025), estimated glomerular filtration rate (eGFR) (n = 944), and left ventricular mass indexed to height (LVMI) (n = 690). RESULTS:: Normal versus high-normal BP categories failed to differentiate between those participants with a BP above optimal values with versus without multivariate-adjusted target organ changes. However, in those with a normal/high-normal BP with aortic SBP values that were less than 95% confidence interval of healthy participants with optimal BP values (45% of those with a normal/high-normal BP), no unadjusted or multivariate adjusted target organ changes were noted. In contrast, those with a normal/high-normal BP with aortic SBP values that exceeded optimal thresholds, demonstrated unadjusted and multivariate adjusted increases in PWV and LVMI and decreases in eGFR (P < 0.05 to P < 0.005 after multivariate adjustments). CONCLUSION:: In contrast to normal versus high-normal BP categories which do not clearly distinguish normotensives with from those without organ damage, noninvasively determined aortic BP measurements may refine the ability to detect those with a normal/high-normal BP at risk of BP-related cardiovascular damage.
Hendrik L Booysen; Gavin R Norton; Muzi J Maseko; Carlos D Libhaber; Olebogeng H I Majane; Pinhas Sareli; Angela J Woodiwiss
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-1
Journal Detail:
Title:  Journal of hypertension     Volume:  -     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aCardiovascular Pathophysiology and Genomics Research Unit, School of Physiology bSchool of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa *Hendrik L. Booysen, Gavin R. Norton and Angela J. Woodiwiss contributed equally to the writing of this work.
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