Document Detail

Aortic body tumours and hyperplasia in the rat.
MedLine Citation:
PMID:  469658     Owner:  NLM     Status:  MEDLINE    
The histologic features of aortic body neoplasia, hyperplasia, and normal aortico-pulmonary paraganglia were described for a series of 56 rats of several strains. Argyrophilic cytoplasmic granules were demonstrated in chief cells of the aortic body lesions, and electron microscopic examination disclosed the presence of electron-dense, membrane-bound granules in these cells. In a series of ageing rats, hyperplasia and neoplasia of the aortico-pulmonary paraganglia occurred more frequently in female WAG/Rij rats than in males of that strain, and more frequently than in males and females of the BN/Bi strain or of the (WAG X BN)F1 hybrid. No apparent causal relationship to chronic hypoxia could be shown, in that no correlation between the development of aortic body neoplasia or hyperplasia and cardiopulmonary disease was found. Aortic body lesions did not appear to occur as part of a multiple endocrinopathy syndrome, although hyperplasia and neoplasia of various endocrine organs occurred relatively frequently in the WAG/Rij strain.
M J van Zwieten; J D Burek; C Zurcher; C F Hollander
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pathology     Volume:  128     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-112     Citation Subset:  IM    
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MeSH Terms
Aortic Bodies / pathology*,  ultrastructure
Endocrine System Diseases / complications
Endomyocardial Fibrosis / complications
Lung Diseases / complications
Neoplasms / pathology*
Nervous System Diseases / pathology*
Paraganglia, Nonchromaffin / pathology*
Paraganglioma / pathology*
Rats / physiology*

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