Document Detail


Aortic baroreceptor deafferentation in the baboon.
MedLine Citation:
PMID:  2870049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous animal studies have indicated that removal of the aortic baroreceptors causes a moderate increase in arterial pressure that is not fully buffered by receptors in the carotid sinus. However, the role of these separate baroreceptors in the conscious nonhuman primate has not been examined. To address this question, adult male baboons were chronically maintained on a tether system that permitted them to move freely about their cage. With this system, arterial pressure and heart rate could be monitored continuously over 24-h periods with periodic drug administration to test cardiovascular function. Control values of arterial pressure and heart rate were 85.6 +/- 4.0 mmHg and 77.5 +/- 2.9 beats/min, respectively. Following removal of the aortic baroreceptors, arterial pressure rose to 104.6 +/- 5.5 mmHg and heart rate increased to 117.9 +/- 3.1 beats/min. The variability of these parameters did not change following denervation. There was, however, a suppression of the arterial pressure-heart period relationship and an augmentation in the depressor response to ganglionic blockade with hexamethonium. These data indicate that removal of the aortic baroreceptors causes a reduction in the sensitivity of the heart rate baroreflex and subsequent increase in arterial pressure that is a result of an increased sympathetic nervous system function.
Authors:
V S Bishop; J R Haywood; R E Shade; M Siegel; C Hamm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  60     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-05-01     Completed Date:  1986-05-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  798-801     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / innervation*
Autonomic Nerve Block
Blood Pressure / drug effects
Denervation*
Dose-Response Relationship, Drug
Heart Rate
Hexamethonium
Hexamethonium Compounds
Male
Nitroprusside / pharmacology
Papio
Phenylephrine / pharmacology
Pressoreceptors / physiology*
Rest
Chemical
Reg. No./Substance:
0/Hexamethonium Compounds; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine; 60-26-4/Hexamethonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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