| Aortic arch morphogenesis and flow modeling in the chick embryo. | |
| | |
MedLine Citation:
|
PMID: 19337838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Morphogenesis of the "immature symmetric embryonic aortic arches" into the "mature and asymmetric aortic arches" involves a delicate sequence of cell and tissue migration, proliferation, and remodeling within an active biomechanical environment. Both patient-derived and experimental animal model data support a significant role for biomechanical forces during arch development. The objective of the present study is to quantify changes in geometry, blood flow, and shear stress patterns (WSS) during a period of normal arch morphogenesis. Composite three-dimensional (3D) models of the chick embryo aortic arches were generated at the Hamburger-Hamilton (HH) developmental stages HH18 and HH24 using fluorescent dye injection, micro-CT, Doppler velocity recordings, and pulsatile subject-specific computational fluid dynamics (CFD). India ink and fluorescent dyes were injected into the embryonic ventricle or atrium to visualize right or left aortic arch morphologies and flows. 3D morphology of the developing great vessels was obtained from polymeric casting followed by micro-CT scan. Inlet aortic arch flow and cerebral-to-lower body flow split was obtained from 20 MHz pulsed Doppler velocity measurements and literature data. Statistically significant variations of the individual arch diameters along the developmental timeline are reported and correlated with WSS calculations from CFD. CFD simulations quantified pulsatile blood flow distribution from the outflow tract through the aortic arches at stages HH18 and HH24. Flow perfusion to all three arch pairs are correlated with the in vivo observations of common pharyngeal arch defect progression. The complex spatial WSS and velocity distributions in the early embryonic aortic arches shifted between stages HH18 and HH24, consistent with increased flow velocities and altered anatomy. The highest values for WSS were noted at sites of narrowest arch diameters. Altered flow and WSS within individual arches could be simulated using altered distributions of inlet flow streams. Thus, inlet flow stream distributions, 3D aortic sac and aortic arch geometries, and local vascular biologic responses to spatial variations in WSS are all likely to be important in the regulation of arch morphogenesis. |
| | |
Authors:
|
Yajuan Wang; Onur Dur; Michael J Patrick; Joseph P Tinney; Kimimasa Tobita; Bradley B Keller; Kerem Pekkan |
Related Documents
:
|
8557928 - Current status of flow convergence for clinical applications: is it a leaning tower of ... 3705958 - Experiments in surgical voice restoration using valve prostheses. 2232898 - The mechanism of blood flow during closed chest cardiac massage in humans: transesophag... 10677158 - Hydrodynamic evaluation of three artificial aortic valve chambers. 9614278 - The significance of colour velocity and spectral doppler ultrasound in the differentiat... 2979538 - Proteolytic activity in the ectoperitrophic fluid of blood-fed culex nigripalpus. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-01 |
Journal Detail:
|
Title: Annals of biomedical engineering Volume: 37 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-05-05 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
|
Languages: eng Pagination: 1069-81 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, Carnegie Mellon University, 2100 Doherty Hall, Pittsburgh, PA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Animals Aorta, Thoracic / anatomy & histology, embryology*, growth & development, physiology*, radiography Chick Embryo Hemodynamics / physiology Models, Cardiovascular* Morphogenesis Radiographic Image Enhancement Regional Blood Flow Stress, Mechanical Tomography, X-Ray Computed Ventricular Function / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Preparation and quality test of superparamagnetic iron oxide labeled antisense oligodeoxynucleotide ...
Next Document: Grammatical processing of spoken language in child and adult language learners.