| Aortic aneurysm and orchitis due to Wegener's granulomatosis. | |
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MedLine Citation:
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PMID: 19748223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a patient with Wegener's granulomatosis (WG) with involvement of the abdominal aorta, testis, peripheral nerve system, and skin. A 51-year-old man presented at our outpatient clinic with lower back pain. He had a history of smoking, hypertension, and an embryonal carcinoma of the left testis, treated 13 years ago with orchidectomy and chemotherapy. One month earlier, he underwent a partial orchidectomy of the right testis due to testicular swelling. Abdominal computed tomography showed a 3.8 cm wide aneurysm of the distal part of the aorta with inflammation. One week later he was admitted to the hospital with numbness of his hands and feet. Physical examination showed signs of peripheral microemboli. Serological laboratory tests revealed elevated antineutrophil cytoplasmic antibody titers with positive reactions against proteinase-3, indicating Wegener's disease. The chest X-ray was normal. Pathological examination of the right testis showed necrotizing vasculitis of a small artery. He was treated with cyclophosphamide and prednisolone. WG with extrapulmonary involvement occurs infrequently, and reports of manifestations of WG in aorta, testis, the peripheral nerve system, and skin are even more uncommon. Small- and medium-vessel vasculitis can precede large-vessel vasculitis or occur in the absence of small-vessel involvement. Therefore, WG should be included in the work-up of large-vessel vasculitis, which can give rise to periaortic inflammation. |
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Authors:
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R C Minnee; G E L van den Berk; J O Groeneveld; J van Dijk; K Turkcan; M J Visser; A C Vahl |
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Publication Detail:
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Type: Case Reports; In Vitro; Journal Article Date: 2009-09-11 |
Journal Detail:
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Title: Annals of vascular surgery Volume: 23 ISSN: 1615-5947 ISO Abbreviation: Ann Vasc Surg Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2010-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703941 Medline TA: Ann Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 786.e15-9 Citation Subset: IM |
Affiliation:
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Department of Vascular Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aortic Aneurysm, Abdominal / drug therapy, etiology*, radiography Aortography / methods Cyclophosphamide / administration & dosage Drug Therapy, Combination Female Humans Hypesthesia / etiology Immunosuppressive Agents / administration & dosage Male Middle Aged Orchitis / drug therapy, etiology*, pathology Prednisolone / administration & dosage Pulse Therapy, Drug Testis / pathology Tomography, X-Ray Computed Treatment Outcome Wegener Granulomatosis / complications, diagnosis*, drug therapy Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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