Document Detail


Aortic valve calcification in mild primary hyperparathyroidism.
MedLine Citation:
PMID:  22031523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: It is unclear whether cardiovascular disease is present in primary hyperparathyroidism (PHPT).
OBJECTIVE: Aortic valve structure and function were compared in PHPT patients and population-based controls.
DESIGN: This is a case-control study.
SETTING: The study was conducted in a university hospital metabolic bone disease unit.
PARTICIPANTS: We studied 51 patients with PHPT and 49 controls.
OUTCOME MEASURES: We measured the aortic valve calcification area and the transaortic pressure gradient.
RESULTS: Aortic valve calcification area was significantly higher in PHPT (0.24 ± 0.02 vs. 0.17 ± 0.02 cm(2), p<0.01), although there was no difference in the peak transaortic pressure gradient, a functional measure of valvular calcification (5.6 ± 0.3 vs. 6.0 ± 0.3 mm Hg, P = 0.39). Aortic valve calcification area was positively associated with PTH (r = 0.34; P < 0.05) but not with serum calcium, phosphorus, or 25-hydroxyvitamin D levels or with calcium-phosphate product. Serum PTH level remained an independent predictor of aortic valve calcification area after adjustment for age, sex, body mass index, smoking status, history of hypercholesterolemia and hypertension, and estimated glomerular filtration rate.
CONCLUSIONS: Mild PHPT is associated with subclinical aortic valve calcification. PTH, but not serum calcium concentration, predicted aortic valve calcification. PTH was a more important predictor of aortic valve calcification than well-accepted cardiovascular risk factors.
Authors:
Shinichi Iwata; Marcella Donovan Walker; Marco R Di Tullio; Eiichi Hyodo; Zhezhen Jin; Rui Liu; Ralph L Sacco; Shunichi Homma; Shonni J Silverberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-10-26
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  97     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-06     Completed Date:  2012-02-27     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aortic Valve / pathology,  physiopathology,  ultrasonography
Calcinosis / complications*,  pathology,  physiopathology,  ultrasonography
Cardiomyopathies / complications*,  pathology,  physiopathology,  ultrasonography
Case-Control Studies
Echocardiography / methods
Female
Health Status Indicators
Heart Valve Diseases / complications*,  pathology,  physiopathology,  ultrasonography
Humans
Hyperparathyroidism, Primary / complications*,  pathology,  physiopathology,  ultrasonography
Male
Middle Aged
Minerals / metabolism
Grant Support
ID/Acronym/Agency:
K24 DK074457/DK/NIDDK NIH HHS; K24 DK074457/DK/NIDDK NIH HHS; R01 DK066329/DK/NIDDK NIH HHS; R01 DK066329/DK/NIDDK NIH HHS; R37 NS29993/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Minerals
Comments/Corrections

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