| Aortic valve calcification in mild primary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 22031523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: It is unclear whether cardiovascular disease is present in primary hyperparathyroidism (PHPT). OBJECTIVE: Aortic valve structure and function were compared in PHPT patients and population-based controls. DESIGN: This is a case-control study. SETTING: The study was conducted in a university hospital metabolic bone disease unit. PARTICIPANTS: We studied 51 patients with PHPT and 49 controls. OUTCOME MEASURES: We measured the aortic valve calcification area and the transaortic pressure gradient. RESULTS: Aortic valve calcification area was significantly higher in PHPT (0.24 ± 0.02 vs. 0.17 ± 0.02 cm(2), p<0.01), although there was no difference in the peak transaortic pressure gradient, a functional measure of valvular calcification (5.6 ± 0.3 vs. 6.0 ± 0.3 mm Hg, P = 0.39). Aortic valve calcification area was positively associated with PTH (r = 0.34; P < 0.05) but not with serum calcium, phosphorus, or 25-hydroxyvitamin D levels or with calcium-phosphate product. Serum PTH level remained an independent predictor of aortic valve calcification area after adjustment for age, sex, body mass index, smoking status, history of hypercholesterolemia and hypertension, and estimated glomerular filtration rate. CONCLUSIONS: Mild PHPT is associated with subclinical aortic valve calcification. PTH, but not serum calcium concentration, predicted aortic valve calcification. PTH was a more important predictor of aortic valve calcification than well-accepted cardiovascular risk factors. |
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Authors:
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Shinichi Iwata; Marcella Donovan Walker; Marco R Di Tullio; Eiichi Hyodo; Zhezhen Jin; Rui Liu; Ralph L Sacco; Shunichi Homma; Shonni J Silverberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-10-26 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 97 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-06 Completed Date: 2012-02-27 Revised Date: 2013-02-20 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 132-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Columbia University, New York, New York 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Valve / pathology, physiopathology, ultrasonography Calcinosis / complications*, pathology, physiopathology, ultrasonography Cardiomyopathies / complications*, pathology, physiopathology, ultrasonography Case-Control Studies Echocardiography / methods Female Health Status Indicators Heart Valve Diseases / complications*, pathology, physiopathology, ultrasonography Humans Hyperparathyroidism, Primary / complications*, pathology, physiopathology, ultrasonography Male Middle Aged Minerals / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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K24 DK074457/DK/NIDDK NIH HHS; K24 DK074457/DK/NIDDK NIH HHS; R01 DK066329/DK/NIDDK NIH HHS; R01 DK066329/DK/NIDDK NIH HHS; R37 NS29993/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Minerals |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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