| Aortic regurgitation dramatically alters the distribution of atherosclerotic lesions and enhances atherogenesis in mice. | |
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MedLine Citation:
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PMID: 20299687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Hemodynamics plays a critical role in atherogenesis, but the association between flow pattern and preferential localization of lesion is not fully understood. We developed a mouse model of aortic valve regurgitation (AR) to change the aortic flow pattern and observed the effects on plaque formation. METHODS AND RESULTS: High-frequency Doppler ultrasound imaging of 10 untreated C57BL/6J mice and 6 sham-treated low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice revealed consistent antegrade blood flow throughout the aorta and oscillatory flow only along the lesser curvature of the aortic arch. Catheter-induced AR in 7 Ldlr(-/-) mice produced various degrees of diastolic retrograde flow throughout the aorta. After the mice were fed a cholesterol-enriched diet for 6 weeks, the burden of atherosclerotic lesions was increased 6-fold, with the naturally plaque-resistant descending aorta becoming susceptible. The AR severity correlated positively with the lesion burden in the descending thoracic and abdominal aorta but negatively with the lesions in the ascending aorta and aortic arch. CONCLUSIONS: This AR model is valuable for elucidating the relationship between hemodynamics and predisposition of the artery wall to atherosclerosis, because of the significant alterations in local flow patterns and the conversion of large regions in the descending aorta from lesion resistant to lesion prone. |
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Authors:
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Yu-Qing Zhou; Su-Ning Zhu; F Stuart Foster; Myron I Cybulsky; R Mark Henkelman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-18 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 30 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1181-8 Citation Subset: IM |
Affiliation:
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Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. yqzhou@phenogenomics.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / pathology, physiopathology*, ultrasonography Aortic Diseases / diagnosis, etiology*, genetics, physiopathology Aortic Valve Insufficiency / complications*, diagnosis, physiopathology Atherosclerosis / diagnosis, etiology*, genetics, physiopathology Disease Models, Animal Disease Susceptibility Hemodynamics* Mice Mice, Inbred C57BL Mice, Knockout Receptors, LDL / deficiency, genetics Regional Blood Flow Risk Factors Severity of Illness Index Ultrasonography, Doppler, Pulsed |
| Chemical | |
Reg. No./Substance:
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0/Receptors, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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