Document Detail

Aortic atherosclerotic plaque and long-term prognosis in patients with atrial fibrillation-a transesophageal echocardiography study.
MedLine Citation:
PMID:  23047295     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Both left atrial spontaneous echo contrast (LASEC) and aortic atherosclerotic plaque (AoP) ≥ 4.0 mm in thickness are predictors of cardiovascular events after stroke. The aim of this study was to investigate impact of AoP ≥ 4.0 mm or LASEC on cardiovascular events in patients with atrial fibrillation (AF).
METHODS AND RESULTS: One hundred and eight consecutive patients with AF were enrolled and studied. Patients were grouped according to the presence or absence of AoP ≥ 4.0 mm in the proximal aortic arch on transesophageal echocardiography (TEE). Cardiovascular events included death, myocardial infarction, ischemic stroke, systemic embolism and congestive heart failure. During a follow-up period (median, 3.9 years), cardiovascular event-free survival rate was significantly lower in patients with AoP ≥ 4.0 mm than in patients without AoP ≥ 4.0 mm (log-rank, P=0.01). In contrast, patients with LASEC showed a trend toward lower cardiovascular event-free survival than those without LASEC (log-rank, P=0.10). Univariate TEE predictors of cardiovascular events were AoP ≥ 4.0 mm, LASEC and left atrial appendage flow velocity. On multivariate Cox regression analysis, AoP ≥ 4.0 mm was the only TEE predictor of cardiovascular events during follow-up (P=0.02, hazard ratio, 2.6; 95% confidence interval: 1.1-6.0).
CONCLUSIONS: In the present unselected patients with AF, AoP predicted long-term cardiovascular events.
Hiroyuki Okura; Toru Kataoka; Minoru Yoshiyama; Junichi Yoshikawa; Kiyoshi Yoshida
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-10-06
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  77     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-13     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  IM    
Division of Cardiology, Bell Land General Hospital, Sakai, Japan.
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MeSH Terms
Aortic Diseases* / complications,  mortality,  physiopathology
Atrial Fibrillation* / complications,  mortality,  physiopathology
Databases, Factual
Disease-Free Survival
Echocardiography, Transesophageal*
Follow-Up Studies
Middle Aged
Plaque, Atherosclerotic* / complications,  mortality,  physiopathology
Retrospective Studies
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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