Document Detail

Anxiolytics, sedatives, antidepressants, neuroleptics and the risk of fracture.
MedLine Citation:
PMID:  16520889     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Our objective was to study the association between fracture risk and the use of anxiolytics and sedatives (benzodiazepines, etc.), neuroleptics and antidepressants. SUBJECTS AND METHODS: This was a case control study. All cases consisted of subjects who had sustained a fracture during the year 2000 (n=124,655). For each case, three controls (n=373,962) matched for age and gender were randomly drawn from the background population. Exposure was defined as the use of neuroleptics, antidepressants and anxiolytics/sedatives, psychiatric disease (manic depressive states, schizophrenia, other psychoses), and other confounders. The effect of dose was examined as a defined daily dose per day (DDD/day). The values referred to are confounder-adjusted. RESULTS: For anxiolytics and sedatives, there was a small increase in overall fracture risk (OR: around 1.1) even with limited doses (<0.1 DDD/day). No dose-response relationship was observed for anxiolytics and sedatives. For neuroleptics, a limited increase in overall fracture risk was observed (OR: around 1.2 from <0.05 DDD/day with no dose-response relationship). For antidepressants, a dose-response relationship was observed for fracture risk (OR: increasing from 1.15, 95% CI: 1.11-1.19 at <0.15 DDD/day to 1.40, 95% CI: 1.35-1.46 for >or=0.75 DDD/day). The risk of fracture was higher with selective serotonin re-uptake inhibitors than with tricyclic antidepressants. CONCLUSIONS: Small increases in fracture risk were seen with the use of anxiolytics and sedatives and neuroleptics without a dose-response relationship. The increase may be linked to an increased risk of falls. For antidepressants, a dose-response relationship was found, with a higher fracture risk for selective serotonin re-uptake inhibitors.
P Vestergaard; L Rejnmark; L Mosekilde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-07
Journal Detail:
Title:  Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA     Volume:  17     ISSN:  0937-941X     ISO Abbreviation:  Osteoporos Int     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-22     Completed Date:  2007-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100105     Medline TA:  Osteoporos Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  807-16     Citation Subset:  IM    
Department of Endocrinology and Metabolism C, Aarhus University Hospital, Aarhus Sygehus, Tage Hansens Gade 2, 8000, Aarhus C, Denmark.
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MeSH Terms
Aged, 80 and over
Anti-Anxiety Agents / adverse effects*
Antidepressive Agents / adverse effects*
Antipsychotic Agents / adverse effects*
Case-Control Studies
Child, Preschool
Denmark / epidemiology
Dose-Response Relationship, Drug
Fractures, Bone / chemically induced*,  epidemiology
Hospital Records
Hypnotics and Sedatives / adverse effects*
Middle Aged
Odds Ratio
Risk Factors
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Antipsychotic Agents; 0/Hypnotics and Sedatives

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