Document Detail

Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings.
MedLine Citation:
PMID:  11296098     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Panic attacks induced by administration of cholecystokinin tetrapeptide (CCK-4) have been evaluated as a valuable tool to investigate the neurobiological mechanisms involved in panic anxiety. The rationale to study the effects of natriuretic peptides on the CCK-4 response is derived from observations that atrial natriuretic peptide (ANP) is released during panic attacks in humans and has anxiolyticlike actions in various animal models. METHODS: A double-blind, placebo-controlled design was conducted in 9 patients with panic disorder and 9 similar healthy control subjects. After pretreatment with an infusion of 150 microg of ANP or placebo in random order, each subject received 50 microg of CCK-4. Psychopathological parameters as well as physiological measures were sampled before and after CCK-4 administration. RESULTS: After pretreatment with ANP, the number of CCK-4-induced panic attacks decreased from 8 to 6 in patients and from 5 to 2 in controls. Acute Panic Inventory ratings were significantly reduced in patients after ANP vs placebo pretreatment. Infusion of ANP significantly curtailed the CCK-4-induced release of corticotropin in patients. Heart rate variability analysis indicated a sympathetic stimulation by CCK-4 that was inhibited by ANP in patients and controls. CONCLUSIONS: The present study indicates that ANP exerts anxiolyticlike effects on CCK-4-stimulated anxiety attacks in patients with panic disorder. In addition, ANP produced an inhibition of the hypothalamopituitary-adrenocortical system and sympatholytic effects.
K Wiedemann; H Jahn; A Yassouridis; M Kellner
Related Documents :
11668318 - Do varicose veins affect quality of life? results of an international population-based ...
22480798 - Cachexia assessed by bioimpedance vector analysis as a prognostic indicator in chronic ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  58     ISSN:  0003-990X     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-11     Completed Date:  2001-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-7     Citation Subset:  AIM; IM    
Department of Psychiatry and Psychotherapy, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenocorticotropic Hormone / blood
Anti-Anxiety Agents / blood,  therapeutic use*
Anxiety Disorders / blood,  chemically induced,  prevention & control
Area Under Curve
Atrial Natriuretic Factor / blood,  therapeutic use*
Blood Pressure / drug effects,  physiology
Double-Blind Method
Heart Rate / drug effects,  physiology
Hydrocortisone / blood
Panic Disorder / blood,  chemically induced*,  prevention & control*
Prospective Studies
Tetragastrin* / pharmacology
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Placebos; 1947-37-1/Tetragastrin; 50-23-7/Hydrocortisone; 85637-73-6/Atrial Natriuretic Factor; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Advancing paternal age and the risk of schizophrenia.
Next Document:  Preventing recurrent depression using cognitive therapy with and without a continuation phase: a ran...